Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6101144 | 0.86 | LMNA (0.51) | LMNAKMT2AMEN1SLC6A5SMN1; SMN2 | |
| SCHEMBL6368371 | 0.85 | ALDH1A1 (0.49) | LMNAKMT2AMEN1MAPTRAB9A | |
| SCHEMBL6368219 | 0.83 | CTSS (0.43) | ALDH1A1MAPK1L3MBTL1POLBCTSL | |
| SCHEMBL6367586 | 0.82 | LMNA (0.52) | LMNAKMT2AMEN1SLC6A5RAB9A | |
| SCHEMBL4580794 | 0.82 | SYK (0.49) | KMT2AMEN1MAPTALDH1A1MAPK1 | |
| SCHEMBL6367594 | 0.82 | LMNA (0.60) | LMNASMN1; SMN2HPGDALDH1A1MAPK1 | |
| SCHEMBL19209664 | 0.81 | CTSL (0.43) | LMNAKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL6368418 | 0.81 | LMNA (0.50) | LMNAKMT2AMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL2861616 | 0.80 | LMNA (0.58) | LMNARAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL394093 | 0.80 | ALDH1A1 (0.50) | LMNAKMT2ASMN1; SMN2HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050059735-A1 | Cyclic amino acid derivatives useful as pharmaceutical agents | BRYANS JUSTIN STEPHEN (GB) | 2005-03-17 | — | — | US | claimed |
| US-20030216469-A1 | Cyclic amino acid derivatives useful as pharmaceutical agents | BRYANS JUSTIN STEPHEN (GB) | 2003-11-20 | — | — | US | claimed |
| EP-1284960-A1 | CYCLIC AMINO ACID DERIVATIVES USEFUL AS PHARMACEUTICAL AGENTS | WARNER-LAMBERT COMPANY (US) | 2003-02-26 | — | — | EP | claimed |
| WO-2001090052-A1 | CYCLIC AMINO ACID DERIVATIVES USEFUL AS PHARMACEUTICAL AGENTS | WARNER-LAMBERT COMPANY (US) | 2001-11-29 | — | — | WO | claimed |
| US-20050059735-A1 | Cyclic amino acid derivatives useful as pharmaceutical agents | BRYANS JUSTIN STEPHEN (GB) | 2005-03-17 | — | — | US | disclosed |
| US-20030216469-A1 | Cyclic amino acid derivatives useful as pharmaceutical agents | BRYANS JUSTIN STEPHEN (GB) | 2003-11-20 | — | — | US | disclosed |
| EP-1284960-A1 | CYCLIC AMINO ACID DERIVATIVES USEFUL AS PHARMACEUTICAL AGENTS | WARNER-LAMBERT COMPANY (US) | 2003-02-26 | — | — | EP | disclosed |
| WO-2001090052-A1 | CYCLIC AMINO ACID DERIVATIVES USEFUL AS PHARMACEUTICAL AGENTS | WARNER-LAMBERT COMPANY (US) | 2001-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059735-A1 | Cyclic amino acid derivatives useful as pharmaceutical agents | QPCT, ARGLU1, PNISR | LMNA 783/4885GLA 3726/4885KMT2A 3098/4885 |
| US-20030216469-A1 | Cyclic amino acid derivatives useful as pharmaceutical agents | QPCT, ARGLU1, QPCTL | LMNA 653/4885GLA 3410/4885KMT2A 3288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.