SCHEMBL6376455

SCHEMBL6376455

CCCCOc1ccc(S(=O)(=O)CC(C(=O)NO)C2(C)C(=O)NC(=O)N2C(C)CC)cc1

nearest known ligand 0.45

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 13/20 0.45
MMP3 P08254 8/20 0.41
MMP9 P14780 7/20 0.41
MMP7 P09237 5/20 0.41
MMP13 P45452 10/20 0.41
MMP2 P08253 6/20 0.41
MMP14 P50281 2/20 0.41
ADAMTS4 O75173 1/20 0.41
ADAMTS5 Q9UNA0 1/20 0.41
ADAM17 P78536 5/20 0.40
MMP8 P22894 1/20 0.39
PPARG P37231 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6378029 0.90 MMP1 (0.42) MMP1MMP3MMP9MMP7MMP13
SCHEMBL6377102 0.90 MMP2 (0.44) MMP1MMP9MMP7MMP13MMP2
SCHEMBL6378086 0.75 BMP1 (0.45) MMP1MMP9MMP7MMP13MMP2
SCHEMBL6382945 0.69 BMP1 (0.45) MMP1MMP9MMP7MMP13MMP2
SCHEMBL7417303 0.68 MMP1 (0.68) MMP1MMP3MMP9MMP7MMP13
SCHEMBL7411093 0.68 MMP13 (0.60) MMP1MMP3MMP9MMP7MMP13
SCHEMBL7420442 0.67 MMP1 (0.69) MMP1MMP3MMP9MMP7MMP13
SCHEMBL31086993 0.66 MMP13 (0.57) MMP1MMP3MMP9MMP7MMP13
SCHEMBL8108645 0.66 MMP1 (0.70) MMP1MMP3MMP9MMP7MMP13
SCHEMBL7361327 0.65 MMP1 (0.43) MMP1MMP9MMP7MMP13MMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0929519-B1 BETA-SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS UPJOHN CO (US) 2005-02-23 EP claimed
EP-0929519-A1 $g(b)-SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1999-07-21 EP claimed
WO-1998013340-A1 β-SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1998-04-02 WO claimed
EP-0929519-B1 BETA-SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS UPJOHN CO (US) 2005-02-23 EP disclosed
US-6235928-B1 ENZYME INHIBITOR MATRIX METALLOPROTEINASE FAMILY, INCLUDING COLLAGENASE, STROMELYSIN, AND GELATINASE, THE COMPOUNDS OR PHARMACEUTICAL COMPOSITIONS PHARMACIA & UPJOHN COMPANY 2001-05-22 US disclosed
EP-0929519-A1 $g(b)-SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1999-07-21 EP disclosed
WO-1998013340-A1 β-SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1998-04-02 WO disclosed