Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.62 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.62 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
| ▸ | NEK2 | P51955 | 1/20 | 0.50 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6394653 | 0.88 | GRM4 (0.57) | KEAP1NFE2L2SLC40A1MEN1TSHR | |
| SCHEMBL5801171 | 0.88 | LMNA (0.61) | KEAP1NFE2L2MEN1TSHRKMT2A | |
| SCHEMBL6662688 | 0.85 | KEAP1 (0.57) | KEAP1NFE2L2SLC40A1MEN1TSHR | |
| SCHEMBL22315132 | 0.85 | MEN1 (0.67) | KEAP1NFE2L2MEN1TSHRKMT2A | |
| SCHEMBL5956006 | 0.83 | KEAP1 (0.58) | KEAP1NFE2L2MEN1KMT2A | |
| SCHEMBL3806499 | 0.82 | ACLY (0.69) | MEN1KMT2A | |
| SCHEMBL19848609 | 0.81 | SLC40A1 (0.49) | KEAP1NFE2L2SLC40A1MEN1TSHR | |
| SCHEMBL7589375 | 0.81 | MEN1 (0.77) | KEAP1NFE2L2MEN1TSHRKMT2A | |
| SCHEMBL2067538 | 0.80 | ALDH1A1 (0.68) | KEAP1SLC40A1MEN1KMT2A | |
| SCHEMBL7591285 | 0.80 | SLC40A1 (0.59) | KEAP1NFE2L2SLC40A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |