Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 2/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA3 | P07451 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL149788 | 0.78 | ALDH1A1 (0.40) | ALDH1A1ALOX15CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL1855148 | 0.77 | CHRNB2 (0.43) | ALDH1A1KDM4ECHRNB2CHRNB4CHRNA3 | |
| SCHEMBL11201182 | 0.77 | FFAR2 (0.38) | ALDH1A1HSD17B10ALOX15CHRNB2CHRNB4 | |
| SCHEMBL9672759 | 0.75 | CES2 (0.35) | ALDH1A1CES1CES2 | |
| SCHEMBL2096460 | 0.71 | ALDH1A1 (0.45) | ALDH1A1HSD17B10KDM4EHPGDALOX15 | |
| SCHEMBL16021810 | 0.70 | ADRB2 (0.48) | ALDH1A1HSD17B10KDM4EHPGDALOX15 | |
| SCHEMBL3096128 | 0.70 | HSD17B10 (0.46) | ALDH1A1HSD17B10KDM4EHPGDALOX15 | |
| SCHEMBL28535945 | 0.70 | ALDH1A1 (0.43) | ALDH1A1HSD17B10KDM4EHPGDALOX15 | |
| SCHEMBL19809851 | 0.70 | KMT2A (0.35) | ALDH1A1HSD17B10ALOX15CHRNB2CHRNB4 | |
| SCHEMBL8038732 | 0.69 | HSD17B10 (0.44) | ALDH1A1HSD17B10KDM4EHPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050187390-A1 | Bicyclic heteroaryl derivatives | GENELABS TECHNOLOGIES, INC. | 2005-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050187390-A1 | Bicyclic heteroaryl derivatives | HAVCR2, MAVS, ZC3HAV1 | ALDH1A1 2299/4885HSD17B10 868/4885KDM4E 2491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.