Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | AGER | Q15109 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6769197 | 1.00 | ADAMTS4 (0.36) | ADAMTS4ADAMTS5PSEN1PSEN2APH1B | |
| SCHEMBL6324718 | 0.88 | ADAMTS4 (0.34) | ADAMTS4ADAMTS5ALDH1A1HPGDHTR7 | |
| SCHEMBL6324360 | 0.78 | SIGMAR1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6322302 | 0.77 | TDO2 (0.43) | ADAMTS4ALDH1A1MMP1MMP9MMP13 | |
| SCHEMBL6326033 | 0.77 | MMP2 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6323684 | 0.74 | ADAMTS4 (0.62) | ADAMTS4ADAMTS5MMP1MMP9MMP13 | |
| SCHEMBL6323686 | 0.74 | ADAMTS4 (0.62) | ADAMTS4ADAMTS5MMP1MMP9MMP13 | |
| SCHEMBL6321475 | 0.72 | ESR1 (0.49) | ADAMTS4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6321479 | 0.72 | ESR1 (0.49) | ADAMTS4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6325881 | 0.70 | PSEN1 (0.52) | ADAMTS4PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014840-A1 | Thiol sulfonamide metalloprotease inhibitors | PHARMACIA CORPORATION | 2005-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014840-A1 | Thiol sulfonamide metalloprotease inhibitors | MMP12, MMP13, MMP3 | ADAMTS4 33/4885ADAMTS5 23/4885PSEN1 893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.