Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
| ▸ | NOS3 | P29474 | 2/20 | 0.30 |
| ▸ | NOS2 | P35228 | 2/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | USP8 | P40818 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6407332 | 0.95 | CYP1A1 (0.34) | CYP1A1CYP1A2SRCKMO | |
| SCHEMBL6597630 | 0.84 | CES1 (0.36) | CYP1A1CYP1A2NOS3NOS2USP8 | |
| SCHEMBL6597622 | 0.80 | NOS2 (0.43) | ALDH1A1NOS3NOS2USP8 | |
| SCHEMBL7991158 | 0.76 | NOS2 (0.43) | ALDH1A1NOS3NOS2 | |
| SCHEMBL6407055 | 0.70 | HPGD (0.40) | CYP1A2KMOALDH1A1USP8 | |
| SCHEMBL13168838 | 0.69 | NOS2 (0.42) | NOS3NOS2USP8 | |
| SCHEMBL6410245 | 0.68 | ALDH1A1 (0.35) | ALDH1A1NOS3NOS2 | |
| SCHEMBL6407115 | 0.68 | TDP2 (0.55) | — | |
| SCHEMBL6407586 | 0.68 | MAPT (0.40) | ALDH1A1ADORA2AUSP8 | |
| Cleistopholine SCHEMBL6358965 | 0.67 | ALDH1A1 (0.55) | CYP1A1CYP1A2ALDH1A1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202993-B1 | PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES | LAFON LABOR (FR) | 2005-10-19 | — | — | EP | disclosed |
| US-6809096-B1 | SUCH AS 11-METHOXY-7H-PYRIDO(4,3,2-DE)(1,7)PHENANTHROLINE-7-ONE; ANTITUMOR AGENTS | LABORATOIRE L. LAFON (FR) | 2004-10-26 | — | — | US | disclosed |
| EP-1202993-A2 | PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES | LABORATOIRE L. LAFON (FR) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001012632-A2 | PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES | LABORATOIRE L. LAFON (FR) | 2001-02-22 | — | — | WO | disclosed |