Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6937301 | 0.82 | ALDH1A1 (0.55) | KDM4EHPGDLMNAHSD17B10MEN1 | |
| SCHEMBL11750773 | 0.77 | SIRT1 (0.61) | PLK1GAAL3MBTL1SLC6A2SLC6A4 | |
| SCHEMBL1799299 | 0.75 | KDM4E (0.65) | PLK1GAAKDM4EHPGDLMNA | |
| SCHEMBL2865709 | 0.75 | ALDH1A1 (0.43) | L3MBTL1KDM4EHPGDLMNAHSD17B10 | |
| SCHEMBL7074216 | 0.73 | LMNA (0.45) | GAAKDM4EHPGDLMNAHSD17B10 | |
| SCHEMBL18667035 | 0.73 | GAA (0.50) | PLK1GAAPTGDR2KDM4EHPGD | |
| SCHEMBL3365582 | 0.72 | TERT (0.59) | PLK1GAACXCR2KDM4EHPGD | |
| SCHEMBL23018506 | 0.72 | GAA (0.53) | PLK1GAAPTGDR2SLC6A2SLC6A4 | |
| SCHEMBL2344909 | 0.71 | GAA (0.71) | PLK1GAASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14164188 | 0.71 | PLK1 (0.52) | PLK1GAACXCR2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050196819-A1 | Methods and compositions to lower plasma cholesterol levels | ATHEROGENICS PHARMACEUTICALS, INC. | 2005-09-08 | — | — | US | disclosed |
| US-6887712-B1 | Methods and compositions to lower plasma cholesterol levels | ATHEROGENICS, INC. (US) | 2005-05-03 | — | — | US | disclosed |