SCHEMBL641559

SCHEMBL641559

Cc1sc2[nH]c(=O)nc(N)c2c1C

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.46
ABCB1 P08183 2/20 0.40
CDC7 O00311 1/20 0.37
ROCK2 O75116 1/20 0.37
MAP4K4 O95819 1/20 0.37
PIM1 P11309 1/20 0.37
GSK3B P49841 1/20 0.37
HIPK2 Q9H2X6 1/20 0.37
CLK4 Q9HAZ1 1/20 0.37
LIMK1 P53667 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
ADORA3 P0DMS8 1/20 0.35
KDM4E B2RXH2 4/20 0.35
PDPK1 O15530 1/20 0.34
LMNA P02545 2/20 0.34
ALDH1A1 P00352 2/20 0.34
GAA P10253 2/20 0.34
MAPT P10636 2/20 0.34
RAB9A P51151 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL643220 0.98 MAPK1 (0.45) MAPK1ABCB1CDC7ROCK2MAP4K4
SCHEMBL12322236 0.80 QPCT (0.38) MAPK1ABCB1CDC7GAK
SCHEMBL1622467 0.80 MAPK1 (0.32) MAPK1SMN1; SMN2
SCHEMBL1622388 0.80 DHFR (0.32) MAPK1ABCB1GAK
SCHEMBL12322232 0.79 MAPK1 (0.31) MAPK1L3MBTL1
SCHEMBL1621900 0.79 BCAT2 (0.41) L3MBTL1KDM4ELMNAALDH1A1GAA
SCHEMBL12310607 0.79 MAPK1 (0.31) MAPK1GAA
SCHEMBL13982529 0.79 CDK8 (0.40) MAPK1MAP4K4CLK4LIMK1KDM4E
SCHEMBL641950 0.79 ABCB1 (0.40) MAPK1ABCB1CDC7ROCK2MAP4K4
SCHEMBL14767743 0.78 MAPK1 (0.42) MAPK1CDC7ROCK2MAP4K4PIM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 246 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4725476-A2 COMPOSITIONS FOR REDUCING SALTY TASTE AND USES THEREOF Firmenich SA (CH) 2026-04-15 EP claimed
EP-4096714-B1 COMPOSITIONS FOR REDUCING SALTY TASTE AND USES THEREOF FIRMENICH & CIE (CH) 2026-01-28 EP claimed
US-20250387310-A1 COMPOSITIONS THAT ENHANCE THE COOLING EFFECT FIRMENICH INCORPORATED (US) 2025-12-25 US claimed
EP-4525821-A1 COMPOSITIONS THAT ENHANCE THE COOLING EFFECT Firmenich Incorporated (US) 2025-03-26 EP claimed
EP-4251122-B1 COMPOSITIONS THAT ENHANCE THE COOLING EFFECT FIRMENICH INCORPORATED (US) 2025-03-12 EP claimed
CN-119604269-A Composition for enhancing cooling effect 弗门尼舍公司 2025-03-11 CN claimed
WO-2024193071-A1 NEOTAME OFF-FLAVOR IMPROVER, ATOMIZED ESSENCE, AND AEROSOL GENERATING APPARATUS 深圳昱朋科技有限公司 2024-09-26 WO claimed
US-20240238183-A1 COMPOSITIONS THAT ENHANCE THE COOLING EFFECT FIRMENICH INCORPORATED (US) 2024-07-18 US claimed
CN-116268354-B Neotame peculiar smell modifier, atomized essence and aerosol generating device 深圳昱朋科技有限公司 2024-03-26 CN claimed
US-20240058238-A1 COMPOSITIONS THAT ENHANCE THE COOLING EFFECT FIRMENICH INCORPORATED (US) 2024-02-22 US claimed
CN-115279414-A Composition for reducing salty taste and use thereof 弗门尼舍有限公司 2022-11-01 CN claimed
WO-2022155054-A1 COMPOSITIONS THAT ENHANCE THE COOLING EFFECT FIRMENICH INCORPORATED (US) 2022-07-21 WO claimed
WO-2021233973-A1 COMPOSITIONS FOR REDUCING SALTY TASTE AND USES THEREOF FIRMENICH SA (CH) 2021-11-25 WO claimed
EP-2247196-B1 SWEETENER COMPOSITIONS AND METHODS OF MAKING THEM SENOMYX INC (US) 2014-11-26 EP claimed
US-8754088-B2 Sweetner compositions and methods of making them SENOMYX, INC. (US) 2014-06-17 US claimed
US-8440676-B2 Sweetener compositions and methods of making them SENOMYX, INC. (US) 2013-05-14 US claimed
US-20120177584-A1 SWEETENER COMPOSITIONS AND METHODS OF MAKING THEM SENOMYX, INC. (US) 2012-07-12 US claimed
EP-2247196-A2 SWEETENER COMPOSITIONS AND METHODS OF MAKING THEM Senomyx, Inc. (US) 2010-11-10 EP claimed
US-20090292010-A1 SWEETENER COMPOSITIONS AND METHODS OF MAKING THEM SENOMYX, INC. 2009-11-26 US claimed
WO-2009100333-A2 SWEETENER COMPOSITIONS AND METHODS OF MAKING THEM SENOMYX, INC. (US) 2009-08-13 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120177584-A1 SWEETENER COMPOSITIONS AND METHODS OF MAKING THEM SI, TAS2R5, TASP1 MAPK1 4548/4885ABCB1 4361/4885CDC7 3579/4885
US-20250387310-A1 COMPOSITIONS THAT ENHANCE THE COOLING EFFECT TAS2R30, TAS2R1, TAS2R20 MAPK1 2778/4885ABCB1 4361/4885CDC7 4280/4885
US-20090292010-A1 SWEETENER COMPOSITIONS AND METHODS OF MAKING THEM SI, TAS2R5, TASP1 MAPK1 4548/4885ABCB1 4361/4885CDC7 3579/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.