Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 5/20 | 0.46 |
| ▸ | BCR | P11274 | 5/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | ACACA | Q13085 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6415231 | 0.85 | MAPT (0.49) | MAPTLMNASCN5ASCN9AABL1 | |
| SCHEMBL6416570 | 0.84 | PKM (0.47) | HSD11B1L3MBTL1 | |
| SCHEMBL6410682 | 0.84 | MAPT (0.40) | MAPTLMNASCN5ASCN9AABL1 | |
| SCHEMBL6410053 | 0.78 | MGLL (0.42) | ACACBACACA | |
| SCHEMBL6418195 | 0.78 | POLB (0.55) | GAA | |
| SCHEMBL2400087 | 0.78 | MAPT (0.52) | MAPTLMNASCN5ASCN9AABL1 | |
| SCHEMBL6409750 | 0.77 | HPGD (0.47) | LMNAABL1BCRHSD11B1L3MBTL1 | |
| SCHEMBL6410215 | 0.77 | SLC6A7 (0.42) | MAPTLMNAGAA | |
| SCHEMBL6415785 | 0.76 | HTR1A (0.46) | HTR1A | |
| SCHEMBL2577788 | 0.75 | LMNA (0.43) | MAPTLMNASCN5ASCN9AABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | disclosed |