Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 3/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78781 | 0.93 | KDM4E (0.36) | GHSRCHRM5CHRM1PTGDR2KDM4E | |
| SCHEMBL64456 | 0.93 | PPARG (0.39) | GHSRCHRM5CHRM1PTGDR2KDM4E | |
| SCHEMBL10289284 | 0.88 | PPARA (0.36) | GHSRCHRM5CHRM1PTGDR2KDM4E | |
| SCHEMBL78412 | 0.86 | PPARG (0.39) | CHRM5CHRM1PTGDR2KDM4ELMNA | |
| SCHEMBL64503 | 0.85 | PPARA (0.33) | GHSRCHRM5CHRM1PTGDR2KDM4E | |
| SCHEMBL78724 | 0.83 | KDM4E (0.34) | CHRM5CHRM1PTGDR2KDM4ELMNA | |
| SCHEMBL65298 | 0.83 | CHRM5 (0.35) | CHRM5CHRM1 | |
| SCHEMBL64061 | 0.82 | CHRM2 (0.38) | GHSRCHRM5CHRM1PARP1 | |
| SCHEMBL64233 | 0.81 | CHRM5 (0.35) | CHRM5CHRM1PTGDR2KDM4ELMNA | |
| SCHEMBL80037 | 0.81 | ITGB3 (0.32) | PTGDR2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |