Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.32 |
| ▸ | GHSR | Q92847 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL65792 | 0.93 | PPARA (0.39) | PPARAITGB3ITGA2BKDM4ELMNA | |
| SCHEMBL64233 | 0.93 | CHRM5 (0.35) | ITGB3ITGA2BKDM4ELMNACHRM5 | |
| SCHEMBL78724 | 0.91 | KDM4E (0.34) | PPARAITGB3ITGA2BKDM4ELMNA | |
| SCHEMBL80037 | 0.89 | ITGB3 (0.32) | ITGB3ITGA2BKDM4ELMNAPTGDR2 | |
| SCHEMBL64056 | 0.87 | PPARG (0.38) | PPARAITGB3ITGA2BKDM4ELMNA | |
| SCHEMBL78854 | 0.85 | PPARG (0.40) | PPARAITGB3ITGA2BKDM4ELMNA | |
| SCHEMBL64196 | 0.85 | GHSR (0.36) | PPARAKDM4ELMNACHRM5CHRM1 | |
| SCHEMBL78866 | 0.83 | PPARG (0.36) | PPARAITGB3ITGA2BKDM4ELMNA | |
| SCHEMBL64604 | 0.82 | REN (0.52) | CYP3A4 | |
| SCHEMBL65202 | 0.82 | MGLL (0.36) | PPARAKDM4ECHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |