Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.53 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.48 |
| ▸ | SNCA | P37840 | 3/20 | 0.48 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1385749 | 0.84 | ALDH1A1 (0.62) | NPC1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL1925493 | 0.83 | NPC1 (0.73) | NPC1MEN1KMT2ACHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL27540694 | 0.82 | NPC1 (0.61) | NPC1MEN1KMT2ALTB4R2ALDH1A1 | |
| SCHEMBL10532358 | 0.79 | NPC1 (0.59) | NPC1MEN1KMT2ACHRM2CHRM1 | |
| SCHEMBL27565502 | 0.78 | MEN1 (0.74) | NPC1MEN1KMT2ACHRM2CHRM1 | |
| SCHEMBL27323388 | 0.76 | NPC1 (0.50) | NPC1ALDH1A1GLAHTTRAB9A | |
| SCHEMBL4797271 | 0.76 | NPC1 (0.50) | NPC1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL6802291 | 0.76 | MEN1 (0.76) | NPC1MEN1KMT2ACHRM2CHRM1 | |
| SCHEMBL28218883 | 0.76 | HDAC1 (0.54) | NPC1MEN1KMT2ALTB4R2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28901400 | 0.76 | CRHBP (0.58) | NPC1MEN1KMT2ACHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050032789-A1 | Novel compounds useful in pain management | ASTRAZENECA CANADA INC. | 2005-02-10 | — | — | US | disclosed |
| EP-1089965-B1 | Urea derivatives for pain management | ASTRAZENECA AB (SE) | 2004-09-15 | — | — | EP | disclosed |
| US-6777561-B1 | MANAGEMENT OF PAIN; PHENYL-UREA COMPOUNDS | ASTRAZENECA CANADA INC. (CA) | 2004-08-17 | — | — | US | disclosed |
| EP-1089965-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067204-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 1999-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032789-A1 | Novel compounds useful in pain management | OPRL1, OPRK1, OPRM1 | NPC1 1434/4885MEN1 4694/4885KMT2A 4510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.