Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 4/20 | 0.44 |
| ▸ | RORC | P51449 | 4/20 | 0.44 |
| ▸ | AR | P10275 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | ESRRA | P11474 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4965062 | 0.89 | THRB (0.48) | THRBRORCALDH1A1MAPTLMNA | |
| SCHEMBL6433832 | 0.86 | THRA (0.48) | THRBTHRA | |
| SCHEMBL5327698 | 0.78 | RORC (0.62) | THRBRORCMAPTLMNATHRA | |
| SCHEMBL7095446 | 0.78 | THRB (0.47) | THRBRORCMAPTLMNATHRA | |
| SCHEMBL2047460 | 0.78 | THRB (0.51) | THRBRORCLMNATHRASMN1; SMN2 | |
| SCHEMBL7041799 | 0.77 | THRB (0.50) | THRBRORCARTHRA | |
| SCHEMBL25514817 | 0.76 | VCAM1 (0.49) | ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL282202 | 0.76 | THRB (0.52) | THRBRORCARTHRAMEN1 | |
| SCHEMBL7256878 | 0.76 | KIF11 (0.45) | THRBRORCARLMNATHRA | |
| SCHEMBL11039034 | 0.74 | RORC (0.47) | THRBRORCALDH1A1THRAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1033364-B1 | Cyano containing oxamic acids and derivatives as thyroid receptor ligands | PFIZER PROD INC (US) | 2005-02-23 | — | — | EP | disclosed |
| US-6194454-B1 | ANTILIPEMIC AGENTS; ANTIDIABETIC AGENTS; DIETETICS; RHEUMATIC DISEASES; ANTICHOLESTEROL AGENTS; CARDIOVASCULAR DISORDERS; ANTIDEPRESSANTS; BONE DISORDERS | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-1033364-A1 | Cyano containing oxamic acids and derivatives as thyroid receptor ligands | Pfizer Products Inc. (US) | 2000-09-06 | — | — | EP | disclosed |