Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 11/20 | 0.51 |
| ▸ | THRA | P10827 | 9/20 | 0.51 |
| ▸ | RORC | P51449 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4965062 | 0.86 | THRB (0.48) | THRBTHRARORCLMNASMN1; SMN2 | |
| SCHEMBL7095446 | 0.85 | THRB (0.47) | THRBTHRARORCLMNASMN1; SMN2 | |
| SCHEMBL5327698 | 0.85 | RORC (0.62) | THRBTHRARORCLMNASMN1; SMN2 | |
| SCHEMBL2047915 | 0.84 | THRA (0.65) | THRBTHRA | |
| SCHEMBL5041163 | 0.82 | THRB (0.52) | THRBTHRARORC | |
| SCHEMBL7256878 | 0.82 | KIF11 (0.45) | THRBTHRARORCLMNASMN1; SMN2 | |
| SCHEMBL8893247 | 0.81 | THRB (0.57) | THRBTHRARORC | |
| SCHEMBL8892589 | 0.80 | THRB (0.53) | THRBTHRARORC | |
| SCHEMBL16496567 | 0.80 | THRB (0.53) | THRBTHRARORC | |
| SCHEMBL5047511 | 0.79 | THRB (0.48) | THRBTHRARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7956214-B2 | Process for the preparation of aniline-derived thyroid receptor ligands | KARO BIO AB (SE) | 2011-06-07 | — | — | US | disclosed |
| US-20100081634-A1 | Novel Phosphorus-Containing Thyromimetics | METABASIS THERAPEUTICS, INC. (US) | 2010-04-01 | — | — | US | disclosed |
| US-20090326263-A1 | Process for the preparation of aniline-derived thyroid receptor ligands | CHIDAMBARAM RAMAKRISHNAN | 2009-12-31 | — | — | US | disclosed |
| US-7514419-B2 | Phosphorus-containing thyromimetics | METABASIS THERAPEUTICS, INC. (US) | 2009-04-07 | — | — | US | disclosed |
| US-20090028925-A1 | Novel Phosphinic Acid-Containing Thyromimetics | METABASIS THERAPEUTICS, INC. | 2009-01-29 | — | — | US | disclosed |
| EP-1891080-A2 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | Metabasis Therapeutics, Inc. (US) | 2008-02-27 | — | — | EP | disclosed |
| EP-1890768-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | Metabasis Therapeutics, Inc. (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006128056-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |
| WO-2006128055-A2 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |
| US-20060046980-A1 | Novel phosphorus-containing thyromimetics | METABASIS THERAPEUTICS, INC. | 2006-03-02 | — | — | US | disclosed |
| US-20050054873-A1 | Process for the preparation of aniline-derived thyroid receptor ligands | KARO BIO AB (SE) | 2005-03-10 | — | — | US | disclosed |
| US-6806381-B2 | SUCH AS N-(3,5-DIBROMO-4-(4-HYDROXY-3-ISOPROPYL-PHENOXY)-PHENYL)-MALONAMIC ACID; FOR TREATMENT OF THYROID DISORDERS | BRISTOL-MYERS SQUIBB COMPANY | 2004-10-19 | — | — | US | disclosed |
| US-20040176425-A1 | Cycloalkyl containing anilide ligands for the thyroid receptor | BRISTOL-MYERS SQUIBB COMPANY | 2004-09-09 | — | — | US | disclosed |
| US-20030157671-A1 | Process for the preparation of aniline-derived thyroid receptor ligands | KARO BIO AB (SE) | 2003-08-21 | — | — | US | disclosed |
| WO-2003039456-A2 | PROCESS FOR THE PREPARATION OF ANILINE-DERIVED THYROID RECEPTOR LIGANDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-05-15 | — | — | WO | disclosed |
| EP-1102739-B1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KAROBIO AB (SE) | 2003-04-23 | — | — | EP | disclosed |
| US-6492424-B1 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2002-12-10 | — | — | US | disclosed |
| EP-1102739-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007972-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2000-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100081634-A1 | Novel Phosphorus-Containing Thyromimetics | PYGL, THRA, THOP1 | THRB 6/4885THRA 2/4885RORC 648/4885 |
| US-20060046980-A1 | Novel phosphorus-containing thyromimetics | PYGL, THRA, THOP1 | THRB 6/4885THRA 2/4885RORC 648/4885 |
| US-20040176425-A1 | Cycloalkyl containing anilide ligands for the thyroid receptor | TSHR, THRB, TRHR | THRB 2/4885THRA 4/4885RORC 417/4885 |
| US-20050054873-A1 | Process for the preparation of aniline-derived thyroid receptor ligands | TSHR, THRA, THRB | THRB 3/4885THRA 2/4885RORC 582/4885 |
| US-20090326263-A1 | Process for the preparation of aniline-derived thyroid receptor ligands | TSHR, THRA, THRB | THRB 3/4885THRA 2/4885RORC 582/4885 |
| US-20030157671-A1 | Process for the preparation of aniline-derived thyroid receptor ligands | TSHR, THRA, THRB | THRB 3/4885THRA 2/4885RORC 582/4885 |
| US-20090028925-A1 | Novel Phosphinic Acid-Containing Thyromimetics | PYGL, PHOSPHO1, LIPE | THRB 41/4885THRA 14/4885RORC 781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.