Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 8/20 | 0.47 |
| ▸ | RORC | P51449 | 4/20 | 0.47 |
| ▸ | THRA | P10827 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4965062 | 0.86 | THRB (0.48) | THRBRORCTHRALMNASMN1; SMN2 | |
| SCHEMBL2047460 | 0.85 | THRB (0.51) | THRBRORCTHRALMNASMN1; SMN2 | |
| SCHEMBL5327698 | 0.85 | RORC (0.62) | THRBRORCTHRALMNASMN1; SMN2 | |
| SCHEMBL7256878 | 0.82 | KIF11 (0.45) | THRBRORCTHRALMNASMN1; SMN2 | |
| SCHEMBL282551 | 0.80 | THRB (0.55) | THRBRORCTHRAMEN1KMT2A | |
| SCHEMBL6435329 | 0.78 | THRB (0.44) | THRBRORCTHRALMNASMN1; SMN2 | |
| SCHEMBL11039034 | 0.78 | RORC (0.47) | THRBRORCTHRATDP1MEN1 | |
| SCHEMBL14264309 | 0.78 | RORC (0.53) | THRBRORCTHRAMAPT | |
| SCHEMBL2962266 | 0.76 | SMN1; SMN2 (0.60) | LMNASMN1; SMN2TDP1MEN1KMT2A | |
| SCHEMBL14264313 | 0.75 | RORC (0.56) | THRBRORCTHRATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030166731-A1 | Method of treating hair loss using diphenylether derivatives | THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER | 2003-09-04 | — | — | US | disclosed |
| US-6525094-B1 | Topical application of compound that interacts strongly with thyroid hormone receptors but sparingly with heart selective hormone receptors | THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER | 2003-02-25 | — | — | US | disclosed |
| EP-1185230-A1 | METHOD OF TREATING HAIR LOSS USING DIPHENYLETHER DERIVATIVES | UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000072812-A1 | METHOD OF TREATING HAIR LOSS USING DIPHENYLETHER DERIVATIVES | THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER (US) | 2000-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166731-A1 | Method of treating hair loss using diphenylether derivatives | CYP27A1, DHCR7, CYP11A1 | THRB 716/4885RORC 1125/4885THRA 1397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.