Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.53 |
| ▸ | ABAT | P80404 | 1/20 | 0.53 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.53 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.46 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7626416 | 0.93 | ALDH5A1 (0.47) | ALDH5A1ABATVCAM1TTRALDH1A1 | |
| SCHEMBL28087611 | 0.88 | ALDH5A1 (0.49) | ALDH5A1ABATVCAM1TTRALDH1A1 | |
| SCHEMBL16953837 | 0.86 | TUBB4A (0.43) | ALDH5A1ABATVCAM1TTRALDH1A1 | |
| SCHEMBL16953042 | 0.86 | CRHBP (0.44) | ALDH5A1ABATVCAM1TTRALDH1A1 | |
| SCHEMBL1414586 | 0.85 | ALDH5A1 (0.48) | ALDH5A1ABATVCAM1TTRALDH1A1 | |
| SCHEMBL1414587 | 0.81 | ALDH1A1 (0.51) | ALDH5A1ABATVCAM1TTRALDH1A1 | |
| SCHEMBL346541 | 0.79 | TUBB4A (0.66) | ALDH5A1ABATVCAM1TTRALDH1A1 | |
| SCHEMBL1275605 | 0.79 | HSPB1 (0.51) | MAPTLMNAKMT2AHTTCRHBP | |
| SCHEMBL397137 | 0.79 | HSPB1 (0.56) | TTRALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL30062398 | 0.79 | HSPB1 (0.56) | TTRALDH1A1MAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106170486-A | Novel indazolecarboxamides, method for the production thereof, pharmaceutical preparations containing the same and use thereof for producing medicaments | 拜耳医药股份有限公司 | 2016-11-30 | — | — | CN | disclosed |
| EP-1194429-B1 | POTASSIUM CHANNEL OPENERS | ABBOTT LAB (US) | 2005-03-30 | — | — | EP | disclosed |
| US-6593335-B1 | Disease than can be ameliorated with a potassium channel opener in a host mammal, comprising administering to the mammal in need thereof a therapeutically effective amount of the compound of claim 1; said disease is epilepsy, Raynaud's | ABBOTT LABORATORIES | 2003-07-15 | — | — | US | disclosed |