SCHEMBL6437333

SCHEMBL6437333

NC(=O)N(C(=O)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1Cl

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPM8 Q7Z2W7 1/20 0.38
P2RX1 P51575 1/20 0.38
MAPT P10636 1/20 0.37
GLA P06280 1/20 0.37
HPGD P15428 1/20 0.37
GPBAR1 Q8TDU6 4/20 0.36
TACR1 P25103 1/20 0.36
MRGPRX4 Q96LA9 3/20 0.36
CNR1 P21554 1/20 0.35
CNR2 P34972 1/20 0.35
NR1H2 P55055 1/20 0.35
NR1H3 Q13133 1/20 0.35
LMNA P02545 1/20 0.35
POLB P06746 1/20 0.35
GAA P10253 1/20 0.35
POLQ O75417 1/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34
KMT2A Q03164 1/20 0.34
CES2 O00748 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29866000 1.00 TRPM8 (0.38) TRPM8P2RX1MAPTGLAHPGD
SCHEMBL7753462 0.88 TRPM8 (0.38) TRPM8P2RX1MAPTGPBAR1TACR1
SCHEMBL7748811 0.78 P2RX1 (0.49) TRPM8P2RX1MAPTGPBAR1TACR1
SCHEMBL7754437 0.78 POLB (0.39) TRPM8MAPTHPGDMRGPRX4NR1H2
SCHEMBL2913048 0.70 L3MBTL1 (0.41) TRPM8MAPTHPGDPOLBGAA
SCHEMBL7752514 0.69 NPC1 (0.40) TRPM8MAPTHPGDGPBAR1POLB
SCHEMBL8678020 0.69 TRPM8 (0.45) TRPM8MRGPRX4
SCHEMBL2492700 0.66 CASP1 (0.47) HPGDGAAALDH1A1KMT2ACES2
SCHEMBL27659219 0.65 TSHR (0.41) TRPM8MAPTHPGDPOLBGAA
Benzoylphenylurea SCHEMBL83109 0.65 L3MBTL1 (0.48) TRPM8MAPTHPGDLMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0912502-B1 2-CHLORO-3,5-BIS(TRIFLUOROMETHYL)PHENYL BENZOYL UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME DONGBU HANNONG CHEMICAL CO LTD (KR) 2001-01-17 EP claimed
US-6022882-A POTENT GROWTH-RETARDING ACTIVITY AGAINST PESTS DONGBU HANNONG CHEMICAL CO., LTD. (KR) 2000-02-08 US claimed
EP-0912502-A1 2-CHLORO-3,5-BIS(TRIFLUOROMETHYL)PHENYL BENZOYL UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME Hanwha Corporation (KR) 1999-05-06 EP claimed
WO-1998000394-A1 2-CHLORO-3,5-BIS(TRIFLUOROMETHYL)PHENYL BENZOYL UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME HANWHA CORPORATION (KR) 1998-01-08 WO claimed
US-6875440-B2 Method for controlling termite SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-04-05 US disclosed
US-20040213824-A1 Composition for controlling termite SUMITOMO CHEMICAL COMPANY, LIMITED 2004-10-28 US disclosed
US-20030175319-A1 Method for controlling termite SUMITOMO CHEMICAL COMPANY, LIMITED 2003-09-18 US disclosed
EP-0912502-B1 2-CHLORO-3,5-BIS(TRIFLUOROMETHYL)PHENYL BENZOYL UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME DONGBU HANNONG CHEMICAL CO LTD (KR) 2001-01-17 EP disclosed
US-6022882-A POTENT GROWTH-RETARDING ACTIVITY AGAINST PESTS DONGBU HANNONG CHEMICAL CO., LTD. (KR) 2000-02-08 US disclosed
US-6022882-A POTENT GROWTH-RETARDING ACTIVITY AGAINST PESTS DONGBU HANNONG CHEMICAL CO., LTD. (KR) 2000-02-08 US disclosed
EP-0912502-A1 2-CHLORO-3,5-BIS(TRIFLUOROMETHYL)PHENYL BENZOYL UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME Hanwha Corporation (KR) 1999-05-06 EP disclosed
WO-1998000394-A1 2-CHLORO-3,5-BIS(TRIFLUOROMETHYL)PHENYL BENZOYL UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME HANWHA CORPORATION (KR) 1998-01-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040213824-A1 Composition for controlling termite NOP2, RPL11, SPOUT1 TRPM8 3932/4885P2RX1 1236/4885MAPT 1152/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.