Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 7/20 | 0.47 |
| ▸ | CTSS | P25774 | 9/20 | 0.45 |
| ▸ | CTSK | P43235 | 9/20 | 0.45 |
| ▸ | CTSC | P53634 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 3/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6446787 | 0.87 | CTSS (0.52) | CTSLCTSSCTSKCTSCCTSB | |
| SCHEMBL6442508 | 0.85 | CNR1 (0.40) | CTSLCTSSCTSKCNR1CNR2 | |
| SCHEMBL6446425 | 0.79 | CTSS (0.48) | CTSLCTSSCTSKCTSB | |
| SCHEMBL6019626 | 0.74 | CTSL (0.59) | CTSLCTSSCTSKCTSC | |
| SCHEMBL6446778 | 0.74 | CNR1 (0.43) | CTSLCTSSCTSKCTSBCNR1 | |
| SCHEMBL5597741 | 0.73 | ESR1 (0.46) | — | |
| SCHEMBL6447927 | 0.73 | CTSK (0.52) | CTSLCTSSCTSKCTSB | |
| SCHEMBL8126795 | 0.72 | SRC (0.50) | — | |
| SCHEMBL6449654 | 0.71 | CTSK (0.56) | CTSLCTSSCTSKCTSB | |
| SCHEMBL6444118 | 0.71 | CTSK (0.50) | CTSLCTSSCTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | claimed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | claimed |
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | disclosed |
| WO-2004056755-A2 | COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES | JERENI AG (DE) | 2004-07-08 | — | — | WO | disclosed |