Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 13/20 | 0.52 |
| ▸ | CTSL | P07711 | 11/20 | 0.52 |
| ▸ | CTSB | P07858 | 8/20 | 0.52 |
| ▸ | CTSK | P43235 | 8/20 | 0.51 |
| ▸ | CTSC | P53634 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6444717 | 0.87 | CTSL (0.47) | CTSSCTSLCTSBCTSKCTSC | |
| SCHEMBL6446778 | 0.86 | CNR1 (0.43) | CTSSCTSLCTSBCTSK | |
| SCHEMBL6446425 | 0.84 | CTSS (0.48) | CTSSCTSLCTSBCTSK | |
| SCHEMBL4243720 | 0.80 | KMT2A (0.49) | — | |
| SCHEMBL6264970 | 0.80 | CTSS (0.57) | CTSSCTSLCTSBCTSKCTSC | |
| SCHEMBL17365565 | 0.79 | CTSS (0.56) | CTSSCTSLCTSBCTSK | |
| SCHEMBL17365596 | 0.79 | CTSS (0.56) | CTSSCTSLCTSBCTSK | |
| SCHEMBL7330779 | 0.78 | CTSS (0.54) | CTSSCTSLCTSBCTSK | |
| SCHEMBL14861481 | 0.78 | HDAC1 (0.56) | — | |
| SCHEMBL7746674 | 0.78 | NAAA (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | claimed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | claimed |
| WO-2004056755-A2 | COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES | JERENI AG (DE) | 2004-07-08 | — | — | WO | claimed |
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | disclosed |
| WO-2004056755-A2 | COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES | JERENI AG (DE) | 2004-07-08 | — | — | WO | disclosed |