SCHEMBL6448097

SCHEMBL6448097

O=[PH](O)c1ccccc1Cc1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2 P10415 1/20 0.45
BCL2L1 Q07817 1/20 0.45
HTR2A P28223 1/20 0.42
CALM1 P0DP23 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.41
TSHR P16473 1/20 0.41
ALOX5 P09917 1/20 0.40
PTPN1 P18031 2/20 0.39
PTPN2 P17706 1/20 0.39
PTPN6 P29350 1/20 0.39
KEAP1 Q14145 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
DAO P14920 1/20 0.38
MEN1 O00255 1/20 0.38
CYP3A4 P08684 1/20 0.38
HPGD P15428 1/20 0.38
ALOX15 P16050 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28130657 0.83 BCL2 (0.38) BCL2BCL2L1HTR2ACALM1L3MBTL1
SCHEMBL18037952 0.77 PKM (0.43) DAO
SCHEMBL575314 0.77 GABRA1 (0.44) L3MBTL1
SCHEMBL6549527 0.77 APOBEC3G (0.41) L3MBTL1TSHRHPGDKMT2A
SCHEMBL3948314 0.76 AKR1B1 (0.55) TSHRCYP1A2CYP2C9CYP2C19HPGD
SCHEMBL9761744 0.76 DRD2 (0.45) HTR2AL3MBTL1TSHRCYP1A2CYP2C9
Diphenylmethane SCHEMBL1537806 0.75 CALM1 (0.67) BCL2BCL2L1CALM1TSHRMEN1
SCHEMBL21642989 0.75 APOBEC3G (0.40) L3MBTL1TSHRHPGDKMT2A
SCHEMBL8898555 0.75 PNMT (0.41)
SCHEMBL12017306 0.74 GAA (0.46) TSHRCYP1A2CYP2D6CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6956072-B1 Thermoplastic resin composition and molded object thereof POLYPLASTICS CO., LTD. (JP) 2005-10-18 US disclosed
US-5068425-A Nervous system disorders, intermediates for drugs and as enantiomorphs SOCIETE NATIONALE ELF AQUITAINE (FR) 1991-11-26 US disclosed
US-4983768-A Reacting an organic halide and an oxazaphospholidine in the absence of air, humidity and light SOCIETE NATIONALE ELF AQUITAINE (FR) 1991-01-08 US disclosed
US-4952740-A INTERMEDIATES FOR PRODUCING PHOSPHINATES AND PHOSPHINE OXIDES; FIREPROOFING PLASTICS SOCIETE NATIONALE ELF AQUITAINE (FR) 1990-08-28 US disclosed
EP-0082057-B1 PROCESS FOR PREPARING PHOSPHINAMIDES, APPLICATIONS AND PRODUCTS SOCIETE NATIONALE ELF AQUITAINE (FR) 1986-04-30 EP disclosed
EP-0082057-A2 Process for preparing phosphinamides, applications and products SOCIETE NATIONALE ELF AQUITAINE (FR) 1983-06-22 EP disclosed