Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 4/20 | 0.40 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
| ▸ | GRN | P28799 | 2/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3134491 | 0.79 | NNMT (0.49) | NNMTACACBGRNSORT1GABRA1 | |
| SCHEMBL5224591 | 0.78 | CDK8 (0.39) | TRPA1AAK1MKNK2CA1CA2 | |
| SCHEMBL5197286 | 0.76 | CA1 (0.35) | TRPA1AAK1CA1CA2CA4 | |
| SCHEMBL5197178 | 0.75 | CYP1A2 (0.41) | AAK1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL6462042 | 0.74 | ACACB (0.35) | ACACBTRPA1AAK1CA1CA2 | |
| SCHEMBL3910420 | 0.73 | CHRNB2 (0.38) | ACACBTRPA1AAK1CA1CA2 | |
| SCHEMBL7529061 | 0.72 | CA2 (0.40) | CA1CA2CA4CA7CA9 | |
| SCHEMBL3144727 | 0.70 | NR3C1 (0.44) | NNMTACACBTRPA1MAPTKDM4E | |
| SCHEMBL3256038 | 0.70 | NR3C1 (0.44) | NNMTACACBTRPA1MAPTKDM4E | |
| SCHEMBL3144717 | 0.70 | NR3C1 (0.44) | NNMTACACBTRPA1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556352-A1 | COMPOUNDS CAPABLE OF ACTIVATING CHOLINERGIC RECEPTORS | Targacept, Inc. (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004031151-A1 | COMPOUNDS CAPABLE OF ACTIVATING CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2004-04-15 | — | — | WO | disclosed |