SCHEMBL645300

SCHEMBL645300

CCOc1ccc(C(c2ccc(Nc3ccccc3)cc2)c2ccc(OCC)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.54
MAPT P10636 4/20 0.54
L3MBTL1 Q9Y468 3/20 0.54
KDM4E B2RXH2 3/20 0.54
POLB P06746 1/20 0.54
OPRM1 P35372 1/20 0.54
OPRD1 P41143 1/20 0.54
RAD52 P43351 1/20 0.54
NPSR1 Q6W5P4 1/20 0.54
SLC2A1 P11166 1/20 0.52
ALDH1A1 P00352 2/20 0.51
HPGD P15428 2/20 0.51
NSD2 O96028 1/20 0.51
LMNA P02545 1/20 0.51
MAPK1 P28482 1/20 0.51
HTT P42858 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
MEN1 O00255 4/20 0.50
PTPN7 P35236 1/20 0.50
PTPN12 Q05209 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9479637 0.89 MAPT (0.63) KMT2AMAPTL3MBTL1KDM4EPOLB
SCHEMBL3440767 0.89 MAPT (0.63) KMT2AMAPTL3MBTL1KDM4EPOLB
SCHEMBL7369820 0.86 LTA4H (0.61) KMT2AMAPTL3MBTL1KDM4EALDH1A1
SCHEMBL9514574 0.82 NQO1 (0.70) KMT2AMAPTL3MBTL1KDM4EPOLB
SCHEMBL2490798 0.82 NQO1 (0.70) KMT2AMAPTL3MBTL1KDM4EALDH1A1
SCHEMBL49554 0.82 NQO1 (0.70) KMT2AMAPTL3MBTL1KDM4EPOLB
SCHEMBL645440 0.81 RAB9A (0.63) KMT2AMAPTL3MBTL1KDM4EPOLB
SCHEMBL9658923 0.80 ALDH1A1 (0.68) KMT2AMAPTL3MBTL1POLBALDH1A1
SCHEMBL24747370 0.78 LTA4H (0.59) KMT2AL3MBTL1OPRM1ALDH1A1LMNA
SCHEMBL13721490 0.78 ALDH1A1 (0.65) KMT2AMAPTL3MBTL1POLBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8119317-B2 Electrophotographic photoreceptor, and process cartridge and image forming apparatus using the photoreceptor RICOH COMPANY, LTD. (JP) 2012-02-21 US disclosed
US-8043777-B2 Electrophotographic photoconductor, process cartridge, and image forming apparatus RICOH COMPANY, LTD. (JP) 2011-10-25 US disclosed
US-20090067891-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, PROCESS CARTRIDGE, AND IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2009-03-12 US disclosed
US-20080311499-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, AND PROCESS CARTRIDGE AND IMAGE FORMING APPARATUS USING THE PHOTORECEPTOR RICOH COMPANY, LTD. (JP) 2008-12-18 US disclosed
US-20080085459-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, AND ELECTROPHOTOGRAPHIC APPARATUS RICOH COMPANY, LTD. (JP) 2008-04-10 US disclosed