Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LOX | P28300 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | SCN7A | Q01118 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | TLR4 | O00206 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11143982 | 0.84 | PTGS2 (0.57) | PTGS2LTA4HPDE10ALOXL2NPC1 | |
| SCHEMBL1146160 | 0.82 | LOXL2 (0.58) | PTGS2LTA4HPDE10ALOXL2CHRM5 | |
| SCHEMBL5024073 | 0.82 | PTGS2 (0.50) | PTGS2LTA4HPDE10ALOXL2CHRM5 | |
| SCHEMBL3543339 | 0.82 | LTA4H (0.58) | PTGS2LTA4HPDE10ALOXL2CHRM5 | |
| SCHEMBL646795 | 0.82 | LTA4H (0.50) | PTGS2LTA4HPDE10ALOXL2CHRM5 | |
| SCHEMBL21054861 | 0.80 | NPC1 (0.58) | LTA4HALDH1A1NPC1CYP2D6CYP2C19 | |
| SCHEMBL30518370 | 0.80 | NPC1 (0.58) | LTA4HALDH1A1NPC1CYP2D6CYP2C19 | |
| SCHEMBL568653 | 0.79 | LTA4H (0.50) | PTGS2LTA4HPDE10ALOXL2ALDH1A1 | |
| SCHEMBL147539 | 0.78 | LOXL2 (0.52) | PTGS2LTA4HPDE10ALOXL2ALDH1A1 | |
| SCHEMBL29610302 | 0.78 | LOXL2 (0.52) | PTGS2LTA4HPDE10ALOXL2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119563-B2 | N-substituted azacycles | FMC CORPORATION (US) | 2012-02-21 | — | — | US | disclosed |
| US-8119563-B2 | N-substituted azacycles | FMC CORPORATION (US) | 2012-02-21 | — | — | US | disclosed |
| US-8119563-B2 | N-substituted azacycles | FMC CORPORATION (US) | 2012-02-21 | — | — | US | disclosed |
| WO-2010010435-A2 | FUSED OXAZOLE AND THIAZOLE DERIVATIVES AS TRPMS MODULATORS | GLENMARK PHARMACEUTICAL S.A. (CH) | 2010-01-28 | — | — | WO | disclosed |
| US-20090215821-A1 | N-Substituted Azacycles | FMC CORPORATION | 2009-08-27 | — | — | US | disclosed |
| US-20090215821-A1 | N-Substituted Azacycles | FMC CORPORATION | 2009-08-27 | — | — | US | disclosed |
| US-20090215821-A1 | N-Substituted Azacycles | FMC CORPORATION | 2009-08-27 | — | — | US | disclosed |
| EP-1673083-A4 | N-SUBSTITUTED AZACYCLES | BAYER CROPSCIENCE AG (DE) | 2008-12-17 | — | — | EP | disclosed |
| US-20080039631-A1 | Process For Preparing N-(Substituted Arylmethyl) -4-Substituted-4-(Disubstituted Methyl) Piperidines And Intermediates | BAYER CROP SCIENCE AG (DE) | 2008-02-14 | — | — | US | disclosed |
| US-20080039631-A1 | Process For Preparing N-(Substituted Arylmethyl) -4-Substituted-4-(Disubstituted Methyl) Piperidines And Intermediates | BAYER CROP SCIENCE AG (DE) | 2008-02-14 | — | — | US | disclosed |
| US-20080039631-A1 | Process For Preparing N-(Substituted Arylmethyl) -4-Substituted-4-(Disubstituted Methyl) Piperidines And Intermediates | BAYER CROP SCIENCE AG (DE) | 2008-02-14 | — | — | US | disclosed |
| EP-1794144-A2 | PROCESSES FOR PREPATING N-(SUBSTITUTED ARYLMETHYL)-4-(DISUBSTITUTED METHYL)PIPERIDINES AND INTERMEDIATES | Bayer CropScience AG (DE) | 2007-06-13 | — | — | EP | disclosed |
| EP-1791828-A1 | PROCESS FOR PREPARING N-(SUBSTITUTED ARYLMETHYL)-4-SUBSTITUTED-4- (DISUBSTITUTED METHYL) PIPERIDINES AND INTERMEDIATES | Bayer CropScience AG (DE) | 2007-06-06 | — | — | EP | disclosed |
| EP-1673083-A2 | N-SUBSTITUTED AZACYCLES | FMC CORPORATION (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2006031674-A1 | PROCESS FOR PREPARING N-(SUBSTITUTED ARYLMETHYL)-4-SUBSTITUTED-4- (DISUBSTITUTED METHYL) PIPERIDINES AND INTERMEDIATES | BAYER CROPSCIENCE AG (DE) | 2006-03-23 | — | — | WO | disclosed |
| WO-2006031764-A2 | PROCESSES FOR PREPATING N-(SUBSTITUTED ARYLMETHYL)-4-(DISUBSTITUTED METHYL)PIPERIDINES AND INTERMEDIATES | BAYER CROPSCIENCE AG (DE) | 2006-03-23 | — | — | WO | disclosed |
| WO-2005036961-A2 | N-SUBSTITUTED AZACYCLES | FMC CORPORATION (US) | 2005-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039631-A1 | Process For Preparing N-(Substituted Arylmethyl) -4-Substituted-4-(Disubstituted Methyl) Piperidines And Intermediates | POF1B, ZRANB2, POU5F1 | PTGS2 4214/4885LTA4H 4172/4885PDE10A 4077/4885 |
| US-20090215821-A1 | N-Substituted Azacycles | DDT, UQCRB, DNMT1 | PTGS2 4445/4885LTA4H 3599/4885PDE10A 188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.