Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20325777 | 0.95 | ALDH1A1 (0.56) | ALDH1A1NPC1RAB9APTGDR2GAA | |
| SCHEMBL13199166 | 0.91 | TSHR (0.46) | KMT2APOLBTSHRMAPTKDM4E | |
| SCHEMBL13199136 | 0.85 | TSHR (0.49) | ALDH1A1POLBTSHRKDM4E | |
| SCHEMBL16595716 | 0.84 | MAPT (0.47) | ALDH1A1NPC1RAB9AGAAL3MBTL1 | |
| SCHEMBL1171941 | 0.84 | ACSS2 (0.48) | ALDH1A1RAB9APOLBMAPTTARBP2 | |
| SCHEMBL12014193 | 0.83 | LMNA (0.45) | ALDH1A1NPC1RAB9AL3MBTL1KMT2A | |
| SCHEMBL12004031 | 0.83 | CYP1A1 (0.48) | ALDH1A1NPC1RAB9AL3MBTL1KMT2A | |
| SCHEMBL11839741 | 0.82 | ALDH1A1 (0.49) | ALDH1A1NPC1RAB9AGAAL3MBTL1 | |
| SCHEMBL21501143 | 0.81 | CES2 (0.51) | ALDH1A1NPC1RAB9APTGDR2GAA | |
| SCHEMBL5003336 | 0.80 | NPSR1 (0.47) | GAAKMT2APOLBCES2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6852751-B2 | Difluorobutyric acid metalloprotease inhibitors | THE PROCTER & GAMBLE COMPANY (US) | 2005-02-08 | — | — | US | disclosed |
| US-20030139453-A1 | Difluorobutyric acid metalloprotease inhibitors | THE PROCTER & GAMBLE COMPANY | 2003-07-24 | — | — | US | disclosed |
| EP-1265865-A2 | DIFLUOROBUTYRIC ACID DERIVATIVES AND THEIR USE AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001070693-A2 | DIFLUOROBUTYRIC ACID DERIVATIVES AND THEIR USE AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139453-A1 | Difluorobutyric acid metalloprotease inhibitors | DPEP1, TMPRSS15, FAP | ALDH1A1 251/4885NPC1 1376/4885RAB9A 2263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.