Sugi Predict

Sugi Predict / Compounds / SCHEMBL6459628

SCHEMBL6459628

SCHEMBL6459628

Cc1cccc(C(N)=O)c1F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KAT6A Q92794 2/20 0.46
▸ PARP1 P09874 6/20 0.44
▸ MYC P01106 1/20 0.44
▸ ALDH1A1 P00352 4/20 0.44
▸ HPGD P15428 3/20 0.44
▸ KDM4E B2RXH2 3/20 0.44
▸ HSD17B10 Q99714 2/20 0.44
▸ LMNA P02545 1/20 0.44
▸ HTT P42858 1/20 0.44
▸ L3MBTL1 Q9Y468 1/20 0.44
▸ MAPT P10636 1/20 0.43
▸ TSHR P16473 1/20 0.43
▸ CES2 O00748 1/20 0.42
▸ BCHE P06276 1/20 0.42
▸ CES1 P23141 1/20 0.42
▸ SIRT3 Q9NTG7 1/20 0.41
▸ TDP1 Q9NUW8 1/20 0.41
▸ METAP2 P50579 1/20 0.41
▸ NPC1 O15118 1/20 0.41
▸ POLB P06746 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30608056 0.86 KAT6A (0.43) KAT6APARP1MYCALDH1A1HPGD
SCHEMBL27214503 0.84 ALDH1A1 (0.52) PARP1ALDH1A1HPGDKDM4EHSD17B10
SCHEMBL10644835 0.83 KAT6A (0.49) KAT6AMYCALDH1A1HPGDKDM4E
SCHEMBL5342753 0.81 HPGD (0.53) PARP1ALDH1A1HPGDKDM4EHSD17B10
SCHEMBL698709 0.81 KDM4E (0.61) KAT6AMYCALDH1A1HPGDKDM4E
SCHEMBL10526573 0.81 KAT6A (0.47) KAT6AMYCALDH1A1HPGDKDM4E
SCHEMBL1642296 0.81 KAT6A (0.47) KAT6AMYCALDH1A1HPGDKDM4E
SCHEMBL29945818 0.81 KAT6A (0.47) KAT6AMYCALDH1A1HPGDKDM4E
SCHEMBL879722 0.79 ALDH1A1 (0.52) KAT6AMYCALDH1A1HPGDKDM4E
SCHEMBL18314692 0.79 F10 (0.40) KAT6AMYCALDH1A1HPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102977029-B As 5 HT2ASerotonin receptor modulator is applied to treat 3 phenylpyrazole derivatives of relative illness 艾尼纳制药公司 2017-12-19 — — CN claimed
WO-2024264072-A2 PARP INHIBITORS Stablix, Inc. (US) 2024-12-26 — — WO disclosed
US-12168648-B2 Opioid receptor modulators EPIODYNE, INC. (US) 2024-12-17 — — US disclosed
CN-118044519-A Molecules having pesticidal utility, and intermediates, compositions and methods related thereto 科迪华农业科技有限责任公司 2024-05-17 — — CN disclosed
CN-114555720-B Antifouling additive 阿萨达股份公司 2024-04-05 — — CN disclosed
WO-2024068655-A1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION AG (CH) 2024-04-04 — — WO disclosed
US-20240092746-A1 OPIOID RECEPTOR MODULATORS EPIODYNE, INC. 2024-03-21 — — US disclosed
CN-110072842-B Molecules having pesticidal utility, and intermediates, compositions and methods related thereto 科迪华农业科技有限责任公司 2024-02-02 — — CN disclosed
CN-117425644-A Opioid receptor modulators 埃皮欧黛公司 2024-01-19 — — CN disclosed
CN-116924953-A Meta-diamide compound containing methylthio derivative, and preparation method and application thereof 上海第二工业大学 2023-10-24 — — CN disclosed
EP-3214081-A1 ISOINDOLINE DERIVATIVE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF Kangpu Biopharmaceuticals, Ltd. (CN) 2017-09-06 — — EP disclosed
CN-106661035-A Pyrazolopyrimidine derivatives as inhibitors of bruton's tyrosine kinase 莱德克斯制药公共有限公司 2017-05-10 — — CN disclosed
US-20170008873-A1 COT MODULATORS AND METHODS OF USE THEREOF GILEAD SCIENCES, INC. 2017-01-12 — — US disclosed
CN-105705022-A Agricultural chemicals 瑞戴格作物保护公司 2016-06-22 — — CN disclosed
WO-2016077378-A1 SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN GENENTECH, INC. (US) 2016-05-19 — — WO disclosed
CN-103012378-A 3-phenyl-pyrazole derivatives as modulators of the 5-HT2a serotonin receptor useful for the treatment of disorders related thereto ARENA PHARM INC 2013-04-03 — — CN disclosed
CN-102977029-A 3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto ARENA PHARM INC 2013-03-20 — — CN disclosed
CN-101084195-B As 5-HT2A3-phenyl-pyrazole derivatives useful as serotonin receptor modulators for the treatment of disorders related thereto ARENA PHARM INC 2013-01-02 — — CN disclosed
CN-1791600-A Benzothiazole derivatives as adenosine receptor ligands HOFFMANN LA ROCHE (CH) 2006-06-21 — — CN disclosed
US-20050197350-A1 Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof TAISHO PHARMACEUTICAL CO., LTD. 2005-09-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240092746-A1 OPIOID RECEPTOR MODULATORS OPRM1, OPRK1, OPRL1 KAT6A 1278/4885PARP1 4573/4885MYC 4545/4885
US-12168648-B2 Opioid receptor modulators OPRM1, OPRK1, OPRL1 KAT6A 1278/4885PARP1 4573/4885MYC 4545/4885
US-20050197350-A1 Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof HCRTR2, MCHR1, MCHR2 KAT6A 4241/4885PARP1 2979/4885MYC 2608/4885
US-20170008873-A1 COT MODULATORS AND METHODS OF USE THEREOF BRDT, THRB, HCCS KAT6A 566/4885PARP1 1381/4885MYC 159/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.