Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 12/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | CCR8 | P51685 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6458570 | 0.90 | POLB (0.49) | CHRM1CHRM2CHRM4CHRM5DRD2 | |
| SCHEMBL6457124 | 0.89 | ADRA1D (0.50) | DRD2HTR2AADRA1AHRH1ADRA1B | |
| SCHEMBL6426288 | 0.87 | CNR2 (0.48) | CHRM1DRD2HTR2A | |
| SCHEMBL6465555 | 0.85 | SIGMAR1 (0.51) | SIGMAR1ADRA1AADRA1B | |
| SCHEMBL6462987 | 0.84 | HTR7 (0.47) | ADRA1AHRH1ADRA1B | |
| SCHEMBL6466592 | 0.84 | HTR7 (0.55) | SIGMAR1DRD2HTR2AADRA1AHRH1 | |
| SCHEMBL6465657 | 0.83 | HTR7 (0.57) | DRD2ADRA1AADRA1B | |
| SCHEMBL6461236 | 0.83 | HTR7 (0.46) | CHRM1ADRA1AHRH1ADRA1B | |
| SCHEMBL6470095 | 0.83 | EPHX2 (0.40) | SIGMAR1DRD2HTR2A | |
| SCHEMBL6472358 | 0.83 | DRD4 (0.56) | DRD2MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1012147-B1 | O-SUBSTITUTED HYDROXYCUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC AGENTS | HOFFMANN LA ROCHE (CH) | 2005-11-02 | — | — | EP | disclosed |
| US-6200989-B1 | ADMINISTERING AS UROKINASE PLASMINOGEN ACTIVATOR ANTAGONISTS, ANTITUMOR AND ANTIMETASTASIS AGENTS | HOFFMANN-LA ROCHE INC. | 2001-03-13 | — | — | US | disclosed |