Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.57 |
| ▸ | DRD2 | P14416 | 10/20 | 0.45 |
| ▸ | DRD3 | P35462 | 10/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6457124 | 0.87 | ADRA1D (0.50) | HTR7DRD2DRD3ADRA1DADRA1A | |
| SCHEMBL6462987 | 0.86 | HTR7 (0.47) | HTR7ADRA1DADRA1AADRA1BPOLB | |
| SCHEMBL6466592 | 0.86 | HTR7 (0.55) | HTR7DRD2DRD3ADRA1DADRA1A | |
| SCHEMBL6461236 | 0.85 | HTR7 (0.46) | HTR7ADRA1DADRA1AADRA1BPOLB | |
| SCHEMBL6463130 | 0.85 | POLB (0.51) | HTR7DRD3POLBMEN1ALDH1A1 | |
| SCHEMBL6457611 | 0.84 | SLC6A5 (0.51) | HTR7DRD2DRD3 | |
| SCHEMBL6462598 | 0.84 | HTR7 (0.54) | HTR7DRD2DRD3ADRA1DADRA1A | |
| SCHEMBL6458101 | 0.84 | HTR7 (0.54) | HTR7DRD2DRD3ADRA1DADRA1A | |
| SCHEMBL6462625 | 0.83 | SIGMAR1 (0.52) | DRD2ADRA1AADRA1B | |
| SCHEMBL6467624 | 0.83 | HRH2 (0.55) | HTR7DRD2DRD3ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1012147-B1 | O-SUBSTITUTED HYDROXYCUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC AGENTS | HOFFMANN LA ROCHE (CH) | 2005-11-02 | — | — | EP | disclosed |
| US-6200989-B1 | ADMINISTERING AS UROKINASE PLASMINOGEN ACTIVATOR ANTAGONISTS, ANTITUMOR AND ANTIMETASTASIS AGENTS | HOFFMANN-LA ROCHE INC. | 2001-03-13 | — | — | US | disclosed |