Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 10/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 4/20 | 0.39 |
| ▸ | F11 | P03951 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7043359 | 0.89 | MMP2 (0.42) | MMP2MMP3MMP7PLA2G4ACES1 | |
| SCHEMBL6462329 | 0.86 | PLA2G4A (0.44) | MMP2MMP3MMP7PLA2G4ACES1 | |
| SCHEMBL6467453 | 0.78 | MMP2 (0.55) | MMP2MMP3MMP7PLA2G4ACES1 | |
| SCHEMBL6467558 | 0.77 | FAAH (0.46) | CES1CYP3A4 | |
| SCHEMBL7048555 | 0.76 | MMP2 (0.47) | MMP2MMP3MMP7PLA2G4ACES1 | |
| SCHEMBL6676842 | 0.76 | CTSK (0.57) | MMP2MMP3MMP7PLA2G4ACES1 | |
| SCHEMBL6464471 | 0.75 | PLA2G4A (0.50) | MMP2MMP3MMP7PLA2G4ACES1 | |
| SCHEMBL6466424 | 0.72 | CTSS (0.51) | MMP2MMP3MMP7F2F10 | |
| SCHEMBL7043193 | 0.72 | CTSS (0.51) | MMP2MMP3MMP7F2F10 | |
| SCHEMBL6475526 | 0.71 | FAAH (0.46) | CES1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1516877-A1 | Amine derivatives as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-23 | — | — | EP | disclosed |