SCHEMBL646513

SCHEMBL646513

N#Cc1c(F)cccc1C(F)(F)F

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.44
KDM4E B2RXH2 6/20 0.41
ALDH1A1 P00352 5/20 0.41
HPGD P15428 3/20 0.41
HSD17B10 Q99714 1/20 0.41
AR P10275 6/20 0.41
KIF11 P52732 1/20 0.41
PGR P06401 1/20 0.41
SLC22A12 Q96S37 2/20 0.39
GAA P10253 3/20 0.38
GLA P06280 2/20 0.38
MAPT P10636 2/20 0.38
MAPK1 P28482 1/20 0.38
CACNA1B Q00975 1/20 0.38
APBA1 Q02410 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
HTT P42858 2/20 0.37
KMT2A Q03164 2/20 0.37
LMNA P02545 1/20 0.37
CUL4A Q13619 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1906819 0.87 AR (0.43) L3MBTL1KDM4EALDH1A1HPGDAR
SCHEMBL13525484 0.82 L3MBTL1 (0.47) L3MBTL1KDM4EALDH1A1HPGDHSD17B10
SCHEMBL18190631 0.82 CA1 (0.39) L3MBTL1KDM4EALDH1A1HPGDAR
Cyanide SCHEMBL28871133 0.80 ALDH1A1 (0.47) L3MBTL1KDM4EALDH1A1HPGDHSD17B10
SCHEMBL22904303 0.79 AR (0.43) L3MBTL1KDM4EALDH1A1ARPGR
SCHEMBL186269 0.79 ALDH1A1 (0.50) L3MBTL1KDM4EALDH1A1HPGDHSD17B10
SCHEMBL7868327 0.79 AR (0.46) ARPGRSLC22A12
SCHEMBL163604 0.79 SLC22A12 (0.38) KDM4EALDH1A1HSD17B10SLC22A12GAA
SCHEMBL28248522 0.79 HSD11B1 (0.35) L3MBTL1KDM4EALDH1A1HSD17B10AR
SCHEMBL27176574 0.78 L3MBTL1 (0.39) L3MBTL1KDM4EALDH1A1HPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 280 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115677598-B Preparation method for synthesizing pyrimidinedione compound 南通常佑药业科技有限公司 2024-11-01 CN claimed
CN-109574877-B Preparation method of 2-cyano-3-fluorobenzotrifluoride 南京正荣医药化学有限公司 2021-06-25 CN claimed
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 US claimed
CN-122076474-A Halogen-modified supported noble metal catalyst and application thereof in synthesis of oxaragroli key intermediate 2026-05-26 CN disclosed
US-20260062393-A1 Compounds CTXT PTY LTD (AU) 2026-03-05 US disclosed
EP-4651866-A1 HYDRAZONYL SULTONES AND USES THEREOF The Research Foundation for The State University of New York (US) 2025-11-26 EP disclosed
US-12435040-B2 1,3-substituted cyclobutyl derivatives and uses thereof BAUSCH + LOMB IRELAND LIMITED (IE) 2025-10-07 US disclosed
US-12365655-B2 Compounds CTXT PTY LTD (AU) 2025-07-22 US disclosed
CN-112334466-B Compounds of formula (I) CTXT私人有限公司 2025-05-30 CN disclosed
CN-116603560-B Palladium-loaded carbon nitride and application thereof in photocatalytic reduction of oxarogalli intermediate 福州大学 2025-04-22 CN disclosed
EP-4031533-B1 PROCESS FOR PREPARING ELAGOLIX SODIUM AND INTERMEDIATES THEREOF SCINOPHARM TAIWAN LTD (TW) 2025-01-01 EP disclosed
WO-2000003991-A1 QUINOLINE DERIVATIVES ACTIVE BIOTECH AB (SE) 2000-01-27 WO disclosed
WO-1999055678-A1 QUINOLINE DERIVATIVES ACTIVE BIOTECH AB (SE) 1999-11-04 WO disclosed
US-5942538-A HALOBENZAMIDOXIME DERIVATIVE USED AS NONTOXIC FUNGICIDE NIPPON SODA CO., LTD. (JP) 1999-08-24 US disclosed
US-5874579-A Insecticidal substituted-2.4-diaminoquinazolines related applications FMC CORPORATION (US) 1999-02-23 US disclosed
US-5847005-A Benzamidoxime derivatives, process production thereof, and agrohorticultural bactericide NIPPON SODA CO., LTD. (JP) 1998-12-08 US disclosed
CN-1170404-A Benzamidoxime derivative, process for production thereof, and agrohoricultural bactericide NIPPON SODA CO (JP) 1998-01-14 CN disclosed
EP-0805148-A1 BENZAMIDOXIME DERIVATIVE, PROCESS FOR PRODUCTION THEREOF, AND AGROHORTICULTURAL BACTERICIDE NIPPON SODA CO., LTD. (JP) 1997-11-05 EP disclosed
US-5616718-A USEFUL FOR MAKING 2,4-DIAMINOQUINAZOLINES; INSECTICIDES FMC CORPORATION (US) 1997-04-01 US disclosed
US-5534518-A Insecticidal substituted-2,4-diaminoquinazolines FMC CORPORATION (US) 1996-07-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12435040-B2 1,3-substituted cyclobutyl derivatives and uses thereof TRPV1, TRPV3, TRPV2 L3MBTL1 4704/4885KDM4E 4562/4885ALDH1A1 1031/4885
US-20260062393-A1 Compounds SCN2B, ABCB11, SCN1B L3MBTL1 3817/4885KDM4E 800/4885ALDH1A1 1864/4885
US-12365655-B2 Compounds SLC10A1, ABCB11, PCSK9 L3MBTL1 4863/4885KDM4E 4009/4885ALDH1A1 982/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.