Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 9/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6466340 | 0.89 | LMNA (0.39) | LMNAKMT2ANPC1RAB9AXDH | |
| SCHEMBL6463655 | 0.89 | LMNA (0.39) | LMNAKMT2ANPC1RAB9AXDH | |
| SCHEMBL6462679 | 0.77 | FAAH (0.37) | KMT2ANPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL7045923 | 0.76 | KMT2A (0.46) | LMNAKMT2APTGESRAB9APTGS2 | |
| SCHEMBL6462292 | 0.73 | DAGLA (0.39) | LMNAKMT2ANPC1RAB9AXDH | |
| SCHEMBL6464160 | 0.71 | LMNA (0.39) | LMNAKMT2ANPC1RAB9ATP53 | |
| SCHEMBL6467443 | 0.69 | FAAH (0.36) | LMNANPC1RAB9APTGS2XDH | |
| SCHEMBL6463984 | 0.68 | DAGLA (0.40) | NPC1RAB9ASMN1; SMN2CETP | |
| SCHEMBL6466282 | 0.67 | LMNA (0.39) | LMNAKMT2ANPC1RAB9ATP53 | |
| SCHEMBL7044868 | 0.67 | LMNA (0.37) | LMNAKMT2ANPC1RAB9AXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1516877-A1 | Amine derivatives as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-23 | — | — | EP | disclosed |