Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 2/20 | 0.37 |
| ▸ | NOS1 | P29475 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | MST1R | Q04912 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16705084 | 0.81 | CYP1A2 (0.46) | L3MBTL1SMN1; SMN2CYP1A2HDAC1HDAC8 | |
| SCHEMBL6370641 | 0.79 | HPGDS (0.37) | L3MBTL1SMN1; SMN2HDAC1HDAC8HDAC6 | |
| SCHEMBL30224786 | 0.78 | THRB (0.43) | L3MBTL1SMN1; SMN2CYP1A2HDAC1HDAC8 | |
| SCHEMBL23993199 | 0.78 | THRB (0.43) | L3MBTL1SMN1; SMN2CYP1A2HDAC1HDAC8 | |
| SCHEMBL12524836 | 0.76 | L3MBTL1 (0.53) | L3MBTL1SMN1; SMN2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6607250 | 0.76 | MEN1 (0.51) | L3MBTL1SMN1; SMN2CYP1A2HDAC1HDAC8 | |
| SCHEMBL18083226 | 0.74 | NOS3 (0.46) | NOS3NOS1L3MBTL1SMN1; SMN2 | |
| SCHEMBL23995366 | 0.74 | SLC6A4 (0.38) | L3MBTL1HDAC1HDAC8HDAC6HPGDS | |
| SCHEMBL17962772 | 0.71 | THRB (0.46) | L3MBTL1SMN1; SMN2CYP1A2HPGDSCYP2C9 | |
| SCHEMBL18611217 | 0.70 | L3MBTL1 (0.40) | L3MBTL1SMN1; SMN2CYP1A2HPGDSCYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108595-A1 | PLATELET-ACTIVATING FACTOR RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108595-A1 | PLATELET-ACTIVATING FACTOR RECEPTOR ANTAGONISTS | PTAFR, PAFAH1B2, PAFAH1B3 | MTNR1A 3011/4885MTNR1B 3159/4885NOS3 2269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.