Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.54 |
| ▸ | CCR6 | P51684 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL20575696 | 1.00 | PKM (0.70) | PKMHIF1AKDM4ECYP3A4ALOX12 | |
| SCHEMBL29490828 | 0.99 | PKM (0.71) | PKMHIF1AKDM4ECYP3A4ALOX12 | |
| SCHEMBL137002 | 0.99 | PKM (0.71) | PKMHIF1AKDM4ECYP3A4ALOX12 | |
| Ammonia Solution, Strong SCHEMBL7175009 | 0.97 | PKM (0.70) | PKMHIF1AKDM4ECYP3A4ALOX12 | |
| SCHEMBL7187750 | 0.97 | PKM (0.70) | PKMHIF1AKDM4ECYP3A4ALOX12 | |
| Dimethylamine SCHEMBL15437599 | 0.93 | PKM (0.77) | PKMHIF1AKDM4ECYP3A4ALOX12 | |
| Dimethylamine SCHEMBL19690796 | 0.93 | PKM (0.77) | PKMHIF1AKDM4ECYP3A4ALOX12 | |
| SCHEMBL30144785 | 0.89 | PKM (0.67) | PKMHIF1AKDM4ECYP3A4ALOX12 | |
| SCHEMBL15437521 | 0.89 | PKM (0.63) | PKMHIF1AKDM4ECYP3A4ALOX12 | |
| SCHEMBL9282523 | 0.87 | PKM (0.71) | PKMHIF1AKDM4ECYP3A4ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050054533-A1 | Herbicidal conposition | SYNGENTA CROP PROTECTION, INC. | 2005-03-10 | — | — | US | disclosed |
| EP-1450607-A1 | HERBICIDAL COMPOSITION | Syngenta Participations AG (CH) | 2004-09-01 | — | — | EP | disclosed |
| US-20040038824-A1 | For controlling undesired plant growth | HAESSLIN HANS WALTER (DE) | 2004-02-26 | — | — | US | disclosed |
| EP-1330438-A1 | AGROCHEMICAL COMPOSITION | Syngenta Participations AG (CH) | 2003-07-30 | — | — | EP | disclosed |
| WO-2003047342-A1 | HERBICIDAL COMPOSITION | SYNGENTA PARTICIPATIONS AG (CH) | 2003-06-12 | — | — | WO | disclosed |
| WO-2002036566-A1 | AGROCHEMICAL COMPOSITION | SYNGENTA PARTICIPATIONS AG (CH) | 2002-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054533-A1 | Herbicidal conposition | DDT, DCPS, DPP7 | MEN1 4114/4885PKM 3033/4885HIF1A 4718/4885 |
| US-20040038824-A1 | For controlling undesired plant growth | CYP2W1, CYP51A1, CYP1A2 | MEN1 1571/4885PKM 2189/4885HIF1A 3500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.