Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.68 |
| ▸ | PDE6D | O43924 | 2/20 | 0.68 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.68 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.68 |
| ▸ | ESR1 | P03372 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8025467 | 0.91 | TP53 (0.74) | ALDH1A1PDE6DALDH2ALDH3A1ESR1 | |
| SCHEMBL5579681 | 0.84 | ALDH1A1 (0.62) | ALDH1A1PDE6DALDH2ALDH3A1ESR1 | |
| SCHEMBL15474496 | 0.84 | ALDH1A1 (0.80) | ALDH1A1PDE6DALDH2ALDH3A1ESR1 | |
| SCHEMBL29412125 | 0.84 | TP53 (0.72) | ALDH1A1PDE6DALDH2ALDH3A1TP53 | |
| SCHEMBL15568359 | 0.83 | TP53 (0.76) | ALDH1A1PDE6DALDH2ALDH3A1TP53 | |
| SCHEMBL5033448 | 0.82 | LMNA (0.48) | ALDH1A1PDE6DALDH2ALDH3A1ESR1 | |
| SCHEMBL5579878 | 0.82 | CASR (0.54) | ALDH1A1PDE6DALDH2ALDH3A1ESR1 | |
| SCHEMBL28503579 | 0.82 | ALDH1A1 (0.63) | ALDH1A1PDE6DALDH2ALDH3A1TP53 | |
| Hydrochloric Acid SCHEMBL8025351 | 0.82 | KDM4E (0.53) | ALDH1A1PDE6DALDH2ALDH3A1ESR1 | |
| SCHEMBL229828 | 0.82 | ALDH1A1 (1.00) | ALDH1A1PDE6DALDH2ALDH3A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855714-B2 | 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-02-15 | — | — | US | disclosed |
| EP-1404321-A1 | 1-ALKYL-2-ARYL-BENZIMIDAZOLE DERIVATIVES, THEIR USE FOR PRODUCING MEDICAMENTS AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID DERIVATIVES | Schering Aktiengesellschaft (DE) | 2004-04-07 | — | — | EP | disclosed |
| US-20030055057-A1 | 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutial agents as well as pharmaceutical preparations that contain these derivatives | SCHERING AG (DE) | 2003-03-20 | — | — | US | disclosed |
| WO-2003004023-A1 | 1-ALKYL-2-ARYL-BENZIMIDAZOLE DERIVATIVES, THEIR USE FOR PRODUCING MEDICAMENTS AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055057-A1 | 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutial agents as well as pharmaceutical preparations that contain these derivatives | ARG2, MSR1, ARG1 | ALDH1A1 182/4885PDE6D 603/4885ALDH2 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.