Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6484529 | 0.90 | CHRM2 (0.46) | ALDH1A1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL6485532 | 0.83 | KDM4E (0.50) | LMNAMAPTGPR119TP53THRB | |
| SCHEMBL6482957 | 0.82 | KDM4E (0.49) | GPR119THRBMEN1KMT2AKDM1A | |
| SCHEMBL9933431 | 0.78 | FAAH (0.47) | ALDH1A1HTTCHRM2CHRM4CHRM1 | |
| SCHEMBL2867370 | 0.76 | GPR119 (0.53) | LMNAALDH1A1POLBCHRM2CHRM4 | |
| SCHEMBL15179456 | 0.75 | GPR119 (0.51) | LMNANPSR1ALDH1A1MAPTGPR119 | |
| SCHEMBL2862442 | 0.75 | ALDH1A1 (0.60) | LMNAALDH1A1CHRM2CHRM4CHRM1 | |
| SCHEMBL15169418 | 0.75 | GPR119 (0.56) | LMNAALDH1A1MAPTGPR119TP53 | |
| SCHEMBL11932534 | 0.71 | FAAH (0.57) | LMNAALDH1A1CHRM2CHRM4CHRM1 | |
| SCHEMBL8210703 | 0.71 | KMT2A (0.55) | LMNANPSR1ALDH1A1CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1312153-C | Pyrrolopyrimidinone derivatives, process for their preparation and their use | SK CHEMICALS CO LTD (KR) | 2007-04-25 | — | — | CN | disclosed |
| US-6962911-B2 | Pyrrolopyrimidinone derivatives, process of preparation and use | SK CHEMICALS CO., LTD. (KR) | 2005-11-08 | — | — | US | disclosed |
| EP-1257553-B1 | PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE | SK CHEMICALS CO LTD (KR) | 2004-05-26 | — | — | EP | disclosed |
| US-20030171361-A1 | Pyrrolopyrimidinone derivatives, process of preparation and use | SK CHEMICALS CO., LTD. (KR) | 2003-09-11 | — | — | US | disclosed |
| CN-1422271-A | Pyrrolopyrimidinone derivatives, process for their preparation and their use | SK CHEMICALS CO LTD (KR) | 2003-06-04 | — | — | CN | disclosed |
| EP-1257553-A1 | PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE | SK Chemicals Co., Ltd. (KR) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001060825-A1 | PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE | SK CHEMICALS CO., LTD. (KR) | 2001-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171361-A1 | Pyrrolopyrimidinone derivatives, process of preparation and use | CYP2C19, DHPS, SDHA | LMNA 2753/4885NPSR1 2040/4885ALDH1A1 301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.