Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6482957 | 0.91 | KDM4E (0.49) | KDM4EPKMGPR119THRBGAA | |
| SCHEMBL6476320 | 0.83 | LMNA (0.47) | GPR119THRBTP53LMNAMAPT | |
| SCHEMBL6484529 | 0.82 | CHRM2 (0.46) | GPR119MAPTNAMPT | |
| SCHEMBL3923737 | 0.76 | KDM4E (0.64) | KDM4EPKMGPR119STSTP53 | |
| SCHEMBL1088570 | 0.74 | GPR119 (0.61) | KDM4EPKMGPR119THRBSMN1; SMN2 | |
| SCHEMBL29566603 | 0.74 | GPR119 (0.61) | KDM4EPKMGPR119THRBSMN1; SMN2 | |
| SCHEMBL18279997 | 0.72 | KDM4E (0.59) | KDM4EPKMGPR119STSTP53 | |
| SCHEMBL2867370 | 0.72 | GPR119 (0.53) | KDM4EPKMGPR119SMN1; SMN2STS | |
| SCHEMBL20601445 | 0.72 | KDM4E (0.68) | KDM4EPKMGPR119STSTGFBR1 | |
| SCHEMBL24983989 | 0.72 | KDM4E (0.50) | KDM4EPKMGPR119STSTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1312153-C | Pyrrolopyrimidinone derivatives, process for their preparation and their use | SK CHEMICALS CO LTD (KR) | 2007-04-25 | — | — | CN | disclosed |
| US-6962911-B2 | Pyrrolopyrimidinone derivatives, process of preparation and use | SK CHEMICALS CO., LTD. (KR) | 2005-11-08 | — | — | US | disclosed |
| EP-1257553-B1 | PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE | SK CHEMICALS CO LTD (KR) | 2004-05-26 | — | — | EP | disclosed |
| US-20030171361-A1 | Pyrrolopyrimidinone derivatives, process of preparation and use | SK CHEMICALS CO., LTD. (KR) | 2003-09-11 | — | — | US | disclosed |
| CN-1422271-A | Pyrrolopyrimidinone derivatives, process for their preparation and their use | SK CHEMICALS CO LTD (KR) | 2003-06-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171361-A1 | Pyrrolopyrimidinone derivatives, process of preparation and use | CYP2C19, DHPS, SDHA | KDM4E 1887/4885PKM 91/4885GPR119 4142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.