Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.37 |
| ▸ | CACNA1I | Q9P0X4 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6818812 | 0.91 | CHRM4 (0.37) | POLBTP53PTGER4THRBP2RX7 | |
| SCHEMBL6484109 | 0.86 | PTGER4 (0.42) | TP53PTGER4KDM4EALDH1A1HPGD | |
| SCHEMBL6478088 | 0.80 | PTGER4 (0.41) | POLBPTGER4P2RX7S1PR3MAPT | |
| SCHEMBL6477100 | 0.80 | CHRM4 (0.43) | PTGER4P2RX7S1PR3MAPTCACNA1G | |
| SCHEMBL6292842 | 0.76 | PTGER4 (0.42) | POLBTP53PTGER4THRBS1PR3 | |
| SCHEMBL6476858 | 0.75 | TRPA1 (0.49) | PTGER4S1PR3MAPTCACNA1GCACNA1H | |
| SCHEMBL6813648 | 0.73 | NAMPT (0.39) | CACNA1GCACNA1HCACNA1IALDH1A1MAPK1 | |
| SCHEMBL6818605 | 0.72 | ALDH1A1 (0.42) | S1PR3KDM4EALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL6475923 | 0.72 | MAPT (0.46) | POLBTP53THRBMAPTKDM4E | |
| SCHEMBL6289333 | 0.72 | LMNA (0.44) | TP53THRBMAPTKDM4ECYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897223-B2 | Pyridine fused bicyclic metalloproteinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2005-05-24 | — | — | US | disclosed |
| US-20040039012-A1 | Pyridine fused bicyclic metalloproteinase inhibitors | WILSON MICHAEL WILLIAM (US) | 2004-02-26 | — | — | US | disclosed |
| WO-2004014908-A1 | HETEROBICYLCIC METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040039012-A1 | Pyridine fused bicyclic metalloproteinase inhibitors | MMP9, MMP1, MMP2 | POLB 2396/4885TP53 608/4885PTGER4 889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.