Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | YAP1 | P46937 | 2/20 | 0.53 |
| ▸ | REN | P00797 | 2/20 | 0.50 |
| ▸ | CAPN1 | P07384 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.47 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.47 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.47 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.47 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.47 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.47 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.47 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6473778 | 0.89 | YAP1 (0.49) | YAP1CAPN1MEN1KMT2APSMB11 | |
| Hydrochloric Acid SCHEMBL6473826 | 0.86 | KMT2A (0.50) | YAP1CAPN1MEN1KMT2APSMB11 | |
| SCHEMBL6474199 | 0.81 | MAPK1 (0.56) | MAPK1YAP1RENCAPN1CACNA1B | |
| SCHEMBL6474204 | 0.81 | MAPK1 (0.56) | MAPK1YAP1RENCAPN1CACNA1B | |
| SCHEMBL8073093 | 0.80 | REN (0.68) | RENCAPN1ALDH1A1 | |
| SCHEMBL28376535 | 0.80 | REN (0.68) | RENCAPN1ALDH1A1 | |
| SCHEMBL30789039 | 0.80 | REN (0.68) | RENCAPN1ALDH1A1 | |
| SCHEMBL18171935 | 0.80 | REN (0.68) | RENCAPN1ALDH1A1 | |
| SCHEMBL7319373 | 0.80 | REN (0.68) | RENCAPN1ALDH1A1 | |
| SCHEMBL6481485 | 0.80 | CTSK (0.56) | CAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | disclosed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | disclosed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | disclosed |