Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 8/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6496169 | 0.86 | TMEM97 (0.48) | TMEM97SIGMAR1CYP3A4SMN1; SMN2HRH1 | |
| SCHEMBL6497047 | 0.85 | SMN1; SMN2 (0.43) | TMEM97SIGMAR1SMN1; SMN2HRH1ALDH1A1 | |
| SCHEMBL6495760 | 0.84 | TMEM97 (0.44) | GRIN2BTMEM97SIGMAR1CYP3A4HRH1 | |
| SCHEMBL6498302 | 0.83 | CYP1A2 (0.44) | CYP3A4SMN1; SMN2ALDH1A1 | |
| SCHEMBL6496625 | 0.82 | TMEM97 (0.45) | TMEM97SIGMAR1CYP3A4SMN1; SMN2HRH1 | |
| SCHEMBL6487281 | 0.81 | TMEM97 (0.40) | TMEM97SIGMAR1HRH1OPRD1OPRK1 | |
| SCHEMBL6495768 | 0.80 | TMEM97 (0.38) | TMEM97SIGMAR1HRH1ALDH1A1TP53 | |
| SCHEMBL6490718 | 0.80 | ALDH1A1 (0.39) | TMEM97SIGMAR1SMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL6488679 | 0.80 | TMEM97 (0.39) | TMEM97SIGMAR1CYP3A4HRH1USP2 | |
| SCHEMBL6489104 | 0.80 | SIGMAR1 (0.46) | TMEM97SIGMAR1CYP2D6CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6869958-B2 | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2005-03-22 | — | — | US | disclosed |
| US-20040038960-A1 | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors | LI JIE JACK (US) | 2004-02-26 | — | — | US | disclosed |
| WO-2004014909-A1 | FUSED TETRAHYDROPYRIDINE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038960-A1 | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors | MMP9, MMP3, MMP13 | GRIN2B 2765/4885TMEM97 3966/4885SIGMAR1 4243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.