Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 10/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HRH2 | P25021 | 2/20 | 0.37 |
| ▸ | HTR1B | P28222 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR1E | P28566 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6496169 | 0.88 | TMEM97 (0.48) | SMN1; SMN2HSD17B10SIGMAR1TMEM97HTR1A | |
| SCHEMBL6495768 | 0.86 | TMEM97 (0.38) | HSD17B10SIGMAR1TMEM97PDE4DHTR1A | |
| SCHEMBL6495760 | 0.85 | TMEM97 (0.44) | SIGMAR1TMEM97HTR1AHRH2HTR1B | |
| SCHEMBL6485589 | 0.85 | GRIN2B (0.40) | SMN1; SMN2SIGMAR1TMEM97HTR1AHRH2 | |
| SCHEMBL6498455 | 0.85 | TMEM97 (0.37) | HSD17B10SIGMAR1TMEM97PDE4DMEN1 | |
| SCHEMBL6487401 | 0.85 | TMEM97 (0.39) | HSD17B10SIGMAR1TMEM97PDE4DHTR1A | |
| SCHEMBL6498082 | 0.84 | FAAH (0.39) | HSD17B10SIGMAR1TMEM97HTTHTR1A | |
| SCHEMBL6496625 | 0.84 | TMEM97 (0.45) | SMN1; SMN2SIGMAR1TMEM97HTR1AHRH2 | |
| SCHEMBL6502757 | 0.83 | TMEM97 (0.39) | SIGMAR1TMEM97MEN1KMT2ANPSR1 | |
| SCHEMBL6490718 | 0.82 | ALDH1A1 (0.39) | SMN1; SMN2SIGMAR1TMEM97HRH3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6869958-B2 | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2005-03-22 | — | — | US | disclosed |
| US-20040038960-A1 | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors | LI JIE JACK (US) | 2004-02-26 | — | — | US | disclosed |
| WO-2004014909-A1 | FUSED TETRAHYDROPYRIDINE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038960-A1 | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors | MMP9, MMP3, MMP13 | SMN1; SMN2 969/4885HSD17B10 1899/4885SIGMAR1 4243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.