Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.46 |
| ▸ | RAB9A | P51151 | 11/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.46 |
| ▸ | CASP3 | P42574 | 2/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.46 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.44 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12876360 | 0.84 | ENPP3 (0.35) | NPC1RAB9ASMN1; SMN2CASP3SENP8 | |
| SCHEMBL5015991 | 0.81 | ALDH1A1 (0.50) | NPC1RAB9ASMN1; SMN2CASP3SENP8 | |
| SCHEMBL2227527 | 0.80 | NOTUM (0.45) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL28524363 | 0.80 | PTPN11 (0.45) | NPC1RAB9ASMN1; SMN2CASP3SENP8 | |
| SCHEMBL6965803 | 0.80 | HDAC1 (0.50) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL17068993 | 0.77 | RAB9A (0.53) | NPC1RAB9ASMN1; SMN2CASP3SENP8 | |
| SCHEMBL1696172 | 0.76 | ESR2 (0.36) | NPC1RAB9AL3MBTL1TDP1ALDH1A1 | |
| SCHEMBL28494497 | 0.76 | NOTUM (0.49) | MAPK1TDP1TSHRALDH1A1HSD17B10 | |
| SCHEMBL1436020 | 0.75 | DRD2 (0.58) | ENPP3ENPP1TSHRALDH1A1PPARG | |
| SCHEMBL3070904 | 0.73 | ACACB (0.37) | NPC1RAB9ASMN1; SMN2KDM4EPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111978268-A | 1- (4-chlorphenyl) -2-cyclopropyl acetone oxime oxazole methyl ether and application thereof | 湖南大学 | 2020-11-24 | — | — | CN | disclosed |
| WO-2019175464-A1 | COMPOUNDS USEFUL AS INHIBITORS OF SODIUM-CALCIUM EXCHANGER (NCX) | ORION CORPORATION (FI) | 2019-09-19 | — | — | WO | disclosed |
| US-6933322-B2 | Substituted naphthylenes for the treatment of non-insulin dependent diabetes mellitus | WYETH (US) | 2005-08-23 | — | — | US | disclosed |
| US-20030216442-A1 | Substituted naphthylenes for the treatment of non-insulin dependent diabetes mellitus | WYETH | 2003-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216442-A1 | Substituted naphthylenes for the treatment of non-insulin dependent diabetes mellitus | INSR, GPR119, SLC5A1 | NPC1 218/4885RAB9A 1302/4885SMN1; SMN2 1928/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.