Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 11/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR1E | P28566 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6496169 | 0.86 | TMEM97 (0.48) | TMEM97SIGMAR1HRH2HTR2CHTR1E | |
| SCHEMBL6488679 | 0.84 | TMEM97 (0.39) | TMEM97SIGMAR1HRH2HTR2CHTR1E | |
| SCHEMBL6489961 | 0.83 | TMEM97 (0.38) | FAAHTMEM97SIGMAR1DHFRHDAC1 | |
| SCHEMBL6486984 | 0.82 | KDR (0.45) | TMEM97SIGMAR1HRH2HTR2CHTR1E | |
| SCHEMBL6498082 | 0.82 | FAAH (0.39) | FAAHTMEM97SIGMAR1HRH2HTR2C | |
| SCHEMBL6499028 | 0.82 | HTR2B (0.45) | TMEM97SIGMAR1HTR1AHTR2BDRD3 | |
| SCHEMBL6496625 | 0.82 | TMEM97 (0.45) | TMEM97SIGMAR1HDAC1HDAC6HRH2 | |
| SCHEMBL6495760 | 0.81 | TMEM97 (0.44) | TMEM97SIGMAR1HRH2HTR2CHTR1E | |
| SCHEMBL6487473 | 0.80 | SIGMAR1 (0.47) | FAAHTMEM97SIGMAR1PTGDR2 | |
| SCHEMBL6490718 | 0.80 | ALDH1A1 (0.39) | TMEM97SIGMAR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6869958-B2 | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2005-03-22 | — | — | US | disclosed |
| US-20040038960-A1 | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors | LI JIE JACK (US) | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038960-A1 | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors | MMP9, MMP3, MMP13 | FAAH 3450/4885TMEM97 3966/4885SIGMAR1 4243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.