Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 6/20 | 0.56 |
| ▸ | ITGAV | P06756 | 6/20 | 0.56 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.56 |
| ▸ | ITGB6 | P18564 | 2/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.44 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6491322 | 1.00 | ITGB3 (0.56) | ITGB3ITGAVITGB1ITGB6OPRM1 | |
| SCHEMBL6491361 | 0.84 | ITGB3 (0.60) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL6491359 | 0.84 | ITGB3 (0.60) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL6178799 | 0.84 | GABBR2 (0.56) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL6177276 | 0.84 | GABBR2 (0.56) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL6177284 | 0.84 | GABBR2 (0.56) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL5856512 | 0.83 | TBXAS1 (0.53) | ITGB3ITGAVITGB1ITGB6TBXAS1 | |
| SCHEMBL6492125 | 0.82 | ITGB3 (0.44) | ITGB3ITGAVITGB1ITGB6OPRM1 | |
| SCHEMBL7797656 | 0.82 | ITGB3 (0.44) | ITGB3ITGAVITGB1ITGB6OPRM1 | |
| SCHEMBL6493607 | 0.80 | ITGB3 (0.47) | ITGB3ITGAVITGB1ITGB6TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6881736-B1 | Vitronectin receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-19 | — | — | US | disclosed |
| EP-1218005-B1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1218005-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-09 | — | — | EP | disclosed |
| EP-1218005-A2 | VITRONECTIN RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001017959-A2 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-03-15 | — | — | WO | disclosed |