Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 2/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6495180 | 1.00 | CCR5 (0.48) | CCR5CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL31285845 | 0.85 | ALDH1A1 (0.43) | CCR5CHRM1HSD11B1ALDH1A1OPRM1 | |
| SCHEMBL31285871 | 0.82 | LMNA (0.40) | CCR5CHRM1HSD11B1MAPK1OPRL1 | |
| SCHEMBL31286047 | 0.81 | MAPK1 (0.40) | CCR5CHRM1HSD11B1ALDH1A1MAPK1 | |
| SCHEMBL16876801 | 0.81 | CCR5 (0.53) | CCR5CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL31362218 | 0.80 | HPGD (0.47) | CCR5CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL31285897 | 0.80 | EPHX2 (0.41) | HSD11B1ALDH1A1OPRM1 | |
| SCHEMBL2989677 | 0.79 | CHRM1 (0.68) | CCR5CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL6494183 | 0.77 | CCR5 (0.56) | CCR5CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL6494181 | 0.77 | CCR5 (0.56) | CCR5CHRM1CHRM2CHRM4CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6946477-B2 | 3-Substituted piperidines comprising urea functionality, and methods of use thereof | SEPRACOR INC. (US) | 2005-09-20 | — | — | US | disclosed |
| US-20030114436-A1 | 3-substituted piperidines comprising urea functionality, and methods of use thereof | AQUILA BRIAN M (US) | 2003-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114436-A1 | 3-substituted piperidines comprising urea functionality, and methods of use thereof | OPRM1, OPRL1, OPRK1 | CCR5 607/4885CHRM1 200/4885CHRM2 284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.