Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.64 |
| ▸ | PYGM | P11217 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | CASP7 | P55210 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | MTOR | P42345 | 1/20 | 0.57 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.57 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6532182 | 0.92 | KDM4E (0.77) | KDM4ENPSR1PYGMHSD17B10CASP1 | |
| SCHEMBL6503393 | 0.90 | HSD17B10 (0.62) | KDM4ENPSR1PYGMHSD17B10CASP1 | |
| SCHEMBL6500237 | 0.89 | KDM4E (0.62) | KDM4ENPSR1PYGMHSD17B10CASP1 | |
| SCHEMBL6504646 | 0.86 | HSD17B10 (0.58) | KDM4ENPSR1PYGMHSD17B10CASP1 | |
| SCHEMBL6529548 | 0.85 | HSD17B10 (0.54) | KDM4ENPSR1PYGMHSD17B10CASP1 | |
| SCHEMBL6505494 | 0.82 | HSD17B10 (0.58) | KDM4ENPSR1PYGMHSD17B10CASP1 | |
| SCHEMBL5549006 | 0.81 | PYGM (0.72) | KDM4ENPSR1PYGMHSD17B10CASP1 | |
| SCHEMBL6529612 | 0.80 | CASP1 (0.60) | KDM4ENPSR1PYGMHSD17B10CASP1 | |
| SCHEMBL14470780 | 0.78 | PYGM (0.69) | KDM4ENPSR1PYGMHSD17B10CASP1 | |
| SCHEMBL6530642 | 0.78 | KDM4E (1.00) | KDM4ENPSR1HSD17B10CASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005021547-A2 | HETEROCYCLIC CANNABINOID CB2 RECEPTOR ANTAGONISTS | PHARMAXIS PTY LTD. (AU) | 2005-03-10 | — | — | WO | claimed |
| WO-2005021547-A3 | HETEROCYCLIC CANNABINOID CB2 RECEPTOR ANTAGONISTS | PHARMAXIS PTY LTD (AU) | 2005-08-18 | — | — | WO | disclosed |
| WO-2005021547-A2 | HETEROCYCLIC CANNABINOID CB2 RECEPTOR ANTAGONISTS | PHARMAXIS PTY LTD. (AU) | 2005-03-10 | — | — | WO | disclosed |