Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6502488 | 0.80 | ITGB3 (0.34) | CTSK | |
| SCHEMBL6502485 | 0.75 | ITGB3 (0.37) | CTSK | |
| SCHEMBL14431790 | 0.72 | ITGB3 (0.40) | CTSK | |
| SCHEMBL6251493 | 0.64 | RAB9A (0.63) | NPC1RAB9ASMN1; SMN2LMNACTSK | |
| SCHEMBL16798314 | 0.60 | SYK (0.48) | CTSK | |
| SCHEMBL10351345 | 0.59 | ALOX15 (0.49) | LMNA | |
| SCHEMBL7452147 | 0.57 | HTT (0.39) | — | |
| SCHEMBL26696220 | 0.57 | ALDH1A1 (0.50) | NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL3784325 | 0.57 | ALDH1A1 (0.50) | NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL10350549 | 0.56 | ALOX15 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849646-B1 | Chromenone and chromanone derivatives as integrin inhibitors | MERCK PATENT GMBH (DE) | 2005-02-01 | — | — | US | disclosed |