Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.41 |
| ▸ | HTR2A | P28223 | 6/20 | 0.41 |
| ▸ | HTR2C | P28335 | 6/20 | 0.41 |
| ▸ | HTR2B | P41595 | 6/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6493159 | 0.71 | SIGMAR1 (0.47) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL8616884 | 0.70 | DRD2 (0.42) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL6499248 | 0.70 | DGAT1 (0.48) | DRD2SIGMAR1HTR7CHRM2CHRM4 | |
| SCHEMBL6503951 | 0.70 | DRD2 (0.40) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL8000235 | 0.69 | SIGMAR1 (0.49) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL6491393 | 0.69 | HTR7 (0.71) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL8191001 | 0.68 | ADRA1D (0.51) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL6491157 | 0.68 | HTR7 (0.69) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL6489774 | 0.67 | HTR7 (0.43) | DRD2SIGMAR1HTR7SLC18A3ADRA1B | |
| SCHEMBL6492064 | 0.67 | SIGMAR1 (0.70) | DRD2SIGMAR1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6969724-B2 | Compounds | SMITHKLINE BEECHAM-SPA (GB) | 2005-11-29 | — | — | US | disclosed |
| US-20040024218-A1 | Novel compounds | SMITHKLINE BEECHAM SPA | 2004-02-05 | — | — | US | disclosed |
| EP-1129072-A2 | N-SUBSTITUTED AZACYCLES, THEIR PREPARATION AND THEIR USE AS ORL-1 RECEPTOR LIGANDS | Smithkline Beecham S.p.A. (IT) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027815-A2 | N-SUBSTITUTED AZACYCLES, THEIR PREPARATION AND THEIR USE AS ORL-1 RECEPTOR LIGANDS | SMITHKLINE BEECHAM SPA (IT) | 2000-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040024218-A1 | Novel compounds | OXER1, CLIC1, CCR1 | DRD2 1194/4885SIGMAR1 50/4885HTR2A 1914/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.