Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.97 |
| ▸ | RAB9A | P51151 | 8/20 | 0.97 |
| ▸ | NPC1 | O15118 | 7/20 | 0.97 |
| ▸ | MAPT | P10636 | 5/20 | 0.97 |
| ▸ | CASP3 | P42574 | 2/20 | 0.97 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.97 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.97 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.97 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | HPGD | P15428 | 5/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.57 |
| ▸ | CDK1 | P06493 | 1/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30047670 | 0.98 | KDM4E (1.00) | KDM4ERAB9ANPC1MAPTCASP3 | |
| SCHEMBL2682217 | 0.98 | KDM4E (1.00) | KDM4ERAB9ANPC1MAPTCASP3 | |
| SCHEMBL11661055 | 0.85 | KDM4E (0.76) | KDM4ERAB9ANPC1MAPTCASP3 | |
| SCHEMBL25455006 | 0.84 | RAB9A (0.74) | KDM4ERAB9ANPC1MAPTCASP3 | |
| SCHEMBL5053299 | 0.84 | NPC1 (0.87) | KDM4ERAB9ANPC1MAPTCASP3 | |
| SCHEMBL4264688 | 0.83 | KDM4E (0.81) | KDM4ERAB9ANPC1MAPTCASP3 | |
| SCHEMBL7945775 | 0.83 | KDM4E (0.73) | KDM4ERAB9ANPC1MAPTCASP3 | |
| SCHEMBL29737278 | 0.82 | RAB9A (0.71) | KDM4ERAB9ANPC1MAPTCASP3 | |
| SCHEMBL28208371 | 0.82 | RAB9A (0.71) | KDM4ERAB9ANPC1MAPTCASP3 | |
| SCHEMBL28416625 | 0.82 | NPC1 (0.83) | KDM4ERAB9ANPC1MAPTCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6858739-B2 | Indole and benzimidazole 15-lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 2005-02-22 | — | — | US | disclosed |
| US-20040038943-A1 | Indole and benzimidazole 15-lipoxygenase inhibitors | CONNOR DAVID THOMAS (US) | 2004-02-26 | — | — | US | disclosed |
| EP-1294686-A2 | INDOLE DERIVATIVES AND THEIR USE AS 15-LIPOXYGENASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001096299-A2 | INDOLE DERIVATIVES AND THEIR USE AS 15-LIPOXYGENASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038943-A1 | Indole and benzimidazole 15-lipoxygenase inhibitors | ALOX15, ALOX5, ALOX12 | KDM4E 881/4885RAB9A 4162/4885NPC1 868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.