Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | BCHE | P06276 | 4/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.50 |
| ▸ | PTGES | O14684 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | CETP | P11597 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3877833 | 0.84 | BCHE (0.57) | BCHEKDM4EACHEMAOB | |
| SCHEMBL6505515 | 0.81 | BCHE (0.60) | TSHRHSD17B10BCHEPTGESKDM4E | |
| SCHEMBL6500610 | 0.79 | GAA (0.59) | TSHRHSD17B10BCHEFFAR1PTGES | |
| SCHEMBL6501980 | 0.78 | GAA (0.69) | TSHRHSD17B10BCHEFFAR1KDM4E | |
| SCHEMBL6515065 | 0.78 | TSHR (0.55) | TSHRHSD17B10FFAR1PTGESTDP1 | |
| SCHEMBL6499688 | 0.77 | CYP1A2 (0.56) | TSHRHSD17B10BCHEFFAR1KDM4E | |
| SCHEMBL6505391 | 0.77 | TSHR (0.52) | TSHRHSD17B10BCHEPTGESKDM4E | |
| SCHEMBL6497288 | 0.75 | TSHR (0.53) | TSHRHSD17B10BCHEPTGES | |
| SCHEMBL6508701 | 0.75 | KDM4E (0.50) | TSHRHSD17B10BCHEKDM4EACHE | |
| SCHEMBL6506029 | 0.75 | LMNA (0.55) | TSHRHSD17B10BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050143372-A1 | Compounds, pharmaceutical compositions and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. | 2005-06-30 | — | — | US | disclosed |
| US-20050009886-A1 | 1,4-Dihydropyridine derivative with a guaiacoxypropanolamine and/or phenoxypropanolamine moiety | CHEN ING-JUN (TW) | 2005-01-13 | — | — | US | disclosed |
| US-4769374-A | Tetrahydroisoquinoline ethyl esters of 1,4-dihydropyridines and antihypertensive compositions | POLI INDUSTRIA CHIMICA S.P.A. (IT) | 1988-09-06 | — | — | US | disclosed |
| EP-0176053-A1 | 1,4-Dihydropyridine derivatives and pharmaceutical compositions containing them | POLI INDUSTRIA CHIMICA S.p.A. (IT) | 1986-04-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143372-A1 | Compounds, pharmaceutical compositions and methods of use therefor | CCR8, CCL11, CCR5 | TSHR 3179/4885HSD17B10 1726/4885BCHE 945/4885 |
| US-20050009886-A1 | 1,4-Dihydropyridine derivative with a guaiacoxypropanolamine and/or phenoxypropanolamine moiety | ADRB3, ADRB1, ADRA1D | TSHR 1816/4885HSD17B10 2220/4885BCHE 1976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.