Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Florfenicol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.95 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.95 |
| ▸ | MEN1 | O00255 | 1/20 | 0.95 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.95 |
| ▸ | TSHR | P16473 | 2/20 | 0.74 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.49 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.49 |
| ▸ | RPS17 | P08708 | 1/20 | 0.49 |
| ▸ | RPSA | P08865 | 1/20 | 0.49 |
| ▸ | RPS2 | P15880 | 1/20 | 0.49 |
| ▸ | RPL35A | P18077 | 1/20 | 0.49 |
| ▸ | RPL7 | P18124 | 1/20 | 0.49 |
| ▸ | RPL17 | P18621 | 1/20 | 0.49 |
| ▸ | RPS4Y1 | P22090 | 1/20 | 0.49 |
| ▸ | RPS3 | P23396 | 1/20 | 0.49 |
| ▸ | RPS12 | P25398 | 1/20 | 0.49 |
| ▸ | RPL13 | P26373 | 1/20 | 0.49 |
| ▸ | RPL10 | P27635 | 1/20 | 0.49 |
| ▸ | RPL12 | P30050 | 1/20 | 0.49 |
| ▸ | RPL9; RPL9P7; RPL9P8; RPL9P9 | P32969 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Florfenicol SCHEMBL651770 | 0.97 | LMNA (1.00) | LMNACYP3A4MEN1KMT2ATSHR | |
| Florfenicol SCHEMBL29833609 | 0.97 | LMNA (1.00) | LMNACYP3A4MEN1KMT2ATSHR | |
| Florfenicol SCHEMBL3030994 | 0.97 | LMNA (1.00) | LMNACYP3A4MEN1KMT2ATSHR | |
| Florfenicol SCHEMBL3637832 | 0.97 | LMNA (1.00) | LMNACYP3A4MEN1KMT2ATSHR | |
| Florfenicol SCHEMBL49425 | 0.97 | LMNA (1.00) | LMNACYP3A4MEN1KMT2ATSHR | |
| Florfenicol SCHEMBL648260 | 0.96 | LMNA (0.93) | LMNACYP3A4MEN1KMT2ATSHR | |
| Florfenicol SCHEMBL4634861 | 0.96 | LMNA (0.97) | LMNACYP3A4MEN1KMT2ATSHR | |
| Florfenicol SCHEMBL3817292 | 0.95 | LMNA (0.95) | LMNACYP3A4MEN1KMT2ATSHR | |
| Florfenicol SCHEMBL651494 | 0.94 | LMNA (0.88) | LMNACYP3A4MEN1KMT2ATSHR | |
| SCHEMBL12683654 | 0.94 | LMNA (0.93) | LMNACYP3A4MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119667-B2 | Carbonates of fenicol antibiotics | SCHERING-PLOUGH ANIMAL HEALTH CORPORATION (US) | 2012-02-21 | — | — | US | claimed |
| EP-1966129-B1 | CARBONATES OF FENICOL ANTIBIOTICS | SCHERING PLOUGH LTD (CH) | 2011-08-17 | — | — | EP | claimed |
| EP-1966129-A2 | CARBONATES OF FENICOL ANTIBIOTICS | Schering-Plough Ltd. (CH) | 2008-09-10 | — | — | EP | claimed |
| WO-2007079010-A2 | CARBONATES OF FENICOL ANTIBIOTICS | SCHERING-PLOUGH LTD. (CH) | 2007-07-12 | — | — | WO | claimed |
| US-20070155799-A1 | CARBONATES OF FENICOL ANTIBIOTICS | INTERVET INC. | 2007-07-05 | — | — | US | claimed |
| US-8119667-B2 | Carbonates of fenicol antibiotics | SCHERING-PLOUGH ANIMAL HEALTH CORPORATION (US) | 2012-02-21 | — | — | US | disclosed |
| US-8084643-B2 | Nitrogen-containing esters of the secondary alcohol group of florfenicol and of its analogs,including salts; veterinary medicine; nonhydrolyzing as needed to maintain the prodrug in aqueous solution in the subjects system until appropriate; cattle drinking water; bovine respiratory disease | INTERVET INC. (US) | 2011-12-27 | — | — | US | disclosed |
| EP-1966129-B1 | CARBONATES OF FENICOL ANTIBIOTICS | SCHERING PLOUGH LTD (CH) | 2011-08-17 | — | — | EP | disclosed |
| EP-2091909-A1 | WATER-SOLUBLE PRODRUGS OF FLORFENICOL AND ITS ANALOGS | Schering-Plough Ltd. (CH) | 2009-08-26 | — | — | EP | disclosed |
| EP-1966129-A2 | CARBONATES OF FENICOL ANTIBIOTICS | Schering-Plough Ltd. (CH) | 2008-09-10 | — | — | EP | disclosed |
| US-20080188556-A1 | Water-Soluble Prodrugs of Florfenicol and its Analogs | SCHERING-PLOUGH ANIMAL HEALTH CORPORATION | 2008-08-07 | — | — | US | disclosed |
| WO-2008076259-A1 | WATER-SOLUBLE PRODRUGS OF FLORFENICOL AND ITS ANALOGS | SCHERING-PLOUGH LTD. (CH) | 2008-06-26 | — | — | WO | disclosed |
| WO-2007079010-A2 | CARBONATES OF FENICOL ANTIBIOTICS | SCHERING-PLOUGH LTD. (CH) | 2007-07-12 | — | — | WO | disclosed |
| US-20070155799-A1 | CARBONATES OF FENICOL ANTIBIOTICS | INTERVET INC. | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155799-A1 | CARBONATES OF FENICOL ANTIBIOTICS | CYP4F3, TET1, CYP4F2 | LMNA 2548/4885CYP3A4 28/4885MEN1 1940/4885 |
| US-20080188556-A1 | Water-Soluble Prodrugs of Florfenicol and its Analogs | PFAS, ADH5, SI | LMNA 2524/4885CYP3A4 15/4885MEN1 2179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.