Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 1/20 | 0.48 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.48 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | CCR8 | P51685 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23609159 | 0.82 | S1PR3 (0.48) | S1PR2S1PR4S1PR3NOS3NOS2 | |
| SCHEMBL11479968 | 0.79 | S1PR3 (0.34) | S1PR2S1PR4S1PR3NOS3NOS2 | |
| Hydrochloric Acid SCHEMBL32665301 | 0.79 | ALDH1A1 (0.39) | DPP4F2ADRA2AADRA2CLMNA | |
| SCHEMBL6505891 | 0.76 | NOS2 (0.42) | NOS3NOS2CCR1CCR5CCR8 | |
| SCHEMBL19445223 | 0.76 | NOS3 (0.50) | S1PR2S1PR4S1PR3NOS3NOS2 | |
| SCHEMBL23716432 | 0.75 | S1PR3 (0.52) | S1PR2S1PR4S1PR3 | |
| SCHEMBL14480105 | 0.74 | NOS3 (0.48) | S1PR2S1PR4S1PR3NOS3NOS2 | |
| SCHEMBL5666361 | 0.74 | NOS3 (0.48) | S1PR2S1PR4S1PR3NOS3NOS2 | |
| SCHEMBL31482165 | 0.74 | NOS3 (0.48) | S1PR2S1PR4S1PR3NOS3NOS2 | |
| SCHEMBL30320133 | 0.74 | NOS3 (0.48) | S1PR2S1PR4S1PR3NOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140155419-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. | 2014-06-05 | — | — | US | disclosed |
| EP-2736329-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals, Inc. (US) | 2014-06-04 | — | — | EP | disclosed |
| WO-2013019621-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2013-02-07 | — | — | WO | disclosed |
| WO-2005023794-A2 | COMPOUND LIBRARIES OF 4-CARBOXAMIDOPIPERIDINE DERIVATIVES | BIOFOCUS PLC (GB) | 2005-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140155419-A1 | COMPOUNDS AND METHODS | RORC, RORB, RORA | S1PR2 343/4885S1PR4 366/4885S1PR3 291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.